(2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:166519-76-2
Molecular Formula:C₂₉H₃₇N₃O₇
Molecular Weight:539.629
Hs Code.:

(2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 7 articles about (2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 26309-99-9
6-(chloromethyl)-2,3-dihydrobenzo[b][1,4]dioxine

: 166519-76-2
(2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 62 percent / NaOEt / ethanol

2: 86.8 percent / KOH / H₂O

3: Acylase Amano 15000, NaOH, CoCl₂*6H₂O / H₂O / 37 °C / pH=7.5

4: 100 percent / Et₃N / acetone; H₂O

5: HOBT, WSCD*HCl / CH₂Cl₂ / Ambient temperature

6: HCl / ethyl acetate / Ambient temperature

7: HOBT, WSCD / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium hydroxide; WSCD*HCl; Acylase Amano 15000; sodium ethanolate; benzotriazol-1-ol; triethylamine; cobalt(II) chloride; In ethanol; dichloromethane; water; ethyl acetate; acetone;
DOI:10.1021/jm00039a022

Reference yield:

: 158648-33-0
L-3,4(ethylenedioxy)phenylalanine

: 166519-76-2
(2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N / acetone; H₂O

2: HOBT, WSCD*HCl / CH₂Cl₂ / Ambient temperature

3: HCl / ethyl acetate / Ambient temperature

4: HOBT, WSCD / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; WSCD*HCl; benzotriazol-1-ol; triethylamine; In dichloromethane; water; ethyl acetate; acetone;
DOI:10.1021/jm00039a022

Reference yield:

: 166519-74-0
2-Acetylamino-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-propionic acid

: 166519-76-2
(2S,4R)-2-[(S)-1-(Benzyl-methyl-carbamoyl)-2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-ethylcarbamoyl]-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Acylase Amano 15000, NaOH, CoCl₂*6H₂O / H₂O / 37 °C / pH=7.5

2: 100 percent / Et₃N / acetone; H₂O

3: HOBT, WSCD*HCl / CH₂Cl₂ / Ambient temperature

4: HCl / ethyl acetate / Ambient temperature

5: HOBT, WSCD / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; sodium hydroxide; WSCD*HCl; Acylase Amano 15000; benzotriazol-1-ol; triethylamine; cobalt(II) chloride; In dichloromethane; water; ethyl acetate; acetone;
DOI:10.1021/jm00039a022