3-benzenesulfonyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester

Base Information

• Chemical Name: 3-benzenesulfonyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester
• CAS No.: 70367-33-8
• Molecular Formula: C₁₈H₁₅Cl₆N₃O₇S
• Molecular Weight: 630.117
• Mol file: 70367-33-8.mol

Synonyms:

Chemical Property of 3-benzenesulfonyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-benzenesulfonyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester

There total 2 articles about 3-benzenesulfonyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylsulfonylnitromethane (21272-85-5) → 3-benzenesulfonyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester (70367-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) Br₂, NaOAc, CH₂Cl₂, (ii) CH₂N₂, Et₂O

2: aq. Na₂CO₃

With sodium carbonate;

DOI:10.1021/ja00499a064

Reference yield:

bis(2,2,2-trichloroethyl) 2,3-diazabicyclo<2.2.1>hept-5-ene-2,3-dicarboxylate (70481-55-9) + bromo(phenylsulfonyl)formaldoxime (70367-23-6) → 3-benzenesulfonyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isoxazolo[4,5-d]pyridazine-5,6-dicarboxylic acid bis-(2,2,2-trichloro-ethyl) ester (70367-33-8)

Guidance literature:

With sodium carbonate;

DOI:10.1021/ja00499a064

upstream raw materials:

bis(2,2,2-trichloroethyl) 2,3-diazabicyclo<2.2.1>hept-5-ene-2,3-dicarboxylate

bromo(phenylsulfonyl)formaldoxime

phenylsulfonylnitromethane