1-(2-Butoxyphenyl)piperazine

Base Information

• Chemical Name: 1-(2-Butoxyphenyl)piperazine
• CAS No.: 106476-37-3
• Molecular Formula: C14H22N2O
• Molecular Weight: 234.341
• ChEMBL ID: CHEMBL9452
• DSSTox Substance ID: DTXSID60560817
• Wikidata: Q82444419

Synonyms:CHEMBL9452;1-(2-Butoxyphenyl)piperazine;106476-37-3;1-(2-Butoxy-phenyl)-piperazine;SCHEMBL9319475;DTXSID60560817;BDBM50017460;AKOS010941338;PD178834

Chemical Property of 1-(2-Butoxyphenyl)piperazine

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 234.173213330
• Heavy Atom Count: 17
• Complexity: 204

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCOC1=CC=CC=C1N2CCNCC2

Technology Process of 1-(2-Butoxyphenyl)piperazine

There total 3 articles about 1-(2-Butoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-butyl o-nitrophenyl ether (7252-51-9) → 1-(o-butoxyphenyl)piperazine (106476-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 9.27 g / H₂ / 10percent Pd/C / ethanol / 2223.7 Torr

2: 2) Na₂CO₃ / 1, 2) n-BuOH, reflux

With hydrogen; sodium carbonate; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00125a020

Reference yield:

2-butoxyaniline (4469-81-2) + bis-(2-chloroethyl)amine hydrochloride (821-48-7) → 1-(o-butoxyphenyl)piperazine (106476-37-3)

Guidance literature:

With sodium carbonate; Yield given. Multistep reaction; 1, 2) n-BuOH, reflux;

DOI:10.1021/jm00125a020

Reference yield:

→ 1-(o-butoxyphenyl)piperazine (106476-37-3)

Guidance literature:

2-Butoxyanilin, Bis(2-chloraethyl)amin*HCl;

upstream raw materials:

2-butoxyaniline

bis-(2-chloroethyl)amine hydrochloride

n-butyl o-nitrophenyl ether

Downstream raw materials:

1-{5-[4-(2-Butoxy-phenyl)-piperazin-1-ylmethyl]-1-methyl-1H-pyrrol-2-ylmethyl}-azepan-2-one

3-[4-(2-butoxyphenyl)-piperazin-1-yl]-propionitrile

2-[[4-(o-butoxyphenyl)piperazin-1-yl]methyl]benzimidazole-4-carboxylic acid

2-{3-[4-(2-butoxy-phenyl)-piperazin-1-yl]-propyl}-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione

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