L-Glutamic acid, N-[4-[[(1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzo yl]-

Base Information

Chemical Name:L-Glutamic acid, N-[4-[[(1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzo yl]-
CAS No.:106585-65-3
Molecular Formula:C24H22N4O6
Molecular Weight:462.462
Hs Code.:

Synonyms:

Suppliers and Price of L-Glutamic acid, N-[4-[[(1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzo yl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Glutamic acid, N-[4-[[(1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzo yl]-

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[4-[[(1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzo yl]-

There total 4 articles about L-Glutamic acid, N-[4-[[(1,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]benzo yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.5%

: 106585-54-0
diethyl N-<4--6-quinazolinyl>methyl>prop-2-ynylamino>benzoyl>-L-glutamate

: 106585-65-3
N-(4-{N-[(3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-prop-2-ynylamino}benzoyl)-L-glutamic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; at 22 ℃; for 18.5h;
DOI:10.1021/jm00124a018

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 106585-65-3
N-(4-{N-[(3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-prop-2-ynylamino}benzoyl)-L-glutamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 77.3 percent / 1) 130 deg C, 1h, 2.) 180 deg C, 1 h

2: 1.) NaH / 1.) DMF, 30 min., 2.) 25 deg C, 2 h

3: 76.3 percent / N-bromosuccinimide / CCl₄ / 0.33 h / Heating; Irradiation

4: 80.3 percent / CaCO₃ / dimethylamine / 18 h / 80 °C

5: 67.5 percent / 1.00 N NaOH / H₂O; ethanol / 18.5 h / 22 °C

With sodium hydroxide; N-Bromosuccinimide; sodium hydride; calcium carbonate; In tetrachloromethane; ethanol; water; dimethyl amine;
DOI:10.1021/jm00124a018

Reference yield:

: 106585-53-9
<6-(bromomethyl)-4-oxo-3(4H)-quinazolinyl>methyl 2,2-dimethylpropanoate

: 106585-65-3
N-(4-{N-[(3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-prop-2-ynylamino}benzoyl)-L-glutamic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80.3 percent / CaCO₃ / dimethylamine / 18 h / 80 °C

2: 67.5 percent / 1.00 N NaOH / H₂O; ethanol / 18.5 h / 22 °C

With sodium hydroxide; calcium carbonate; In ethanol; water; dimethyl amine;
DOI:10.1021/jm00124a018