1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[(4-chlorophenyl)methyl]-

Base Information

• Chemical Name: 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[(4-chlorophenyl)methyl]-
• CAS No.: 106663-25-6
• Molecular Formula: C15H17ClN2O2
• Molecular Weight: 292.765
• DSSTox Substance ID: DTXSID30368983
• Nikkaji Number: J428.918H
• Wikidata: Q82155914

Synonyms:106663-25-6;3-(4-Chlorobenzyl)-1,3-diazaspiro[4.5]decane-2,4-dione;1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[(4-chlorophenyl)methyl]-;DTXSID30368983;AKOS000835889;Z16394886;3-(p-Chlorobenzyl)-2,4-dioxo-1,3-diazaspiro[4.5]decane

Chemical Property of 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[(4-chlorophenyl)methyl]-

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 292.0978555
• Heavy Atom Count: 20
• Complexity: 399

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2(CC1)C(=O)N(C(=O)N2)CC3=CC=C(C=C3)Cl

Technology Process of 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[(4-chlorophenyl)methyl]-

There total 12 articles about 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[(4-chlorophenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester (467443-12-5) → 3-(4-chlorobenzyl)-1,3-diazaspiro[4.5]decane-2,4-dione (106663-25-6)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

DOI:10.3797/scipharm.aut-01-204

Reference yield: 66.0%

spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione (702-62-5) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 3-(4-chlorobenzyl)-1,3-diazaspiro[4.5]decane-2,4-dione (106663-25-6)

Guidance literature:

spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione; With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

1-Chloro-4-(chloromethyl)benzene; In N,N-dimethyl-formamide; at 80 ℃; for 72h;

DOI:10.1016/j.molstruc.2018.11.071

Reference yield:

spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione (702-62-5) + 4-chlorobenzyl bromide (622-95-7) → 3-(4-chlorobenzyl)-1,3-diazaspiro[4.5]decane-2,4-dione (106663-25-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/c6ce02210c

upstream raw materials:

spiro(imidazolidine-4,1'-cyclohexane)-2,5-dione

1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester

4-chlorophenylacetic Acid

1-aminocyclohexane carboxylic acid

Downstream raw materials:

3-(4-Chloro-benzyl)-4-hydroxy-1,3-diaza-spiro[4.5]decan-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 106663-25-6 1,3-Diazaspiro[4.5]decane-2,4-dione, 3-[(4-chlorophenyl)methyl]-

Send

Send

Metric Ton KG G Pound L ML

Send

Send