(4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde

Base Information

Chemical Name:(4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde
CAS No.:124928-73-0
Molecular Formula:C₉H₁₆O₃
Molecular Weight:172.224
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde

Chemical Property:

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Technology Process of (4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde

There total 9 articles about (4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: (R)-1-((4R,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-ethane-1,2-diol

: 124928-73-0
(4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde

Guidance literature:: With sodium periodate; In water; acetone; at 26 ℃; for 1h;
DOI:10.1246/bcsj.62.2618

Reference yield:

: 67814-68-0,70266-87-4,76249-50-8,76249-51-9,93451-15-1,4099-88-1
2,3-O-isopropylidene-D-ribofuranose

: 124928-73-0
(4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1: 73 percent / Mg / diethyl ether / 3.5 h / 23 °C

2: 1.) NaIO₄, 2.) LiAlH₄ / 1.) 24 deg C, 1 h, aqueous acetone, 2.) THF, 20 deg C, 20 min

3: 97 percent / imidazole / dimethylformamide / 2.66 h / 24 °C

4: pyridinium chlorochromate, molecular sieves 3 Angstroem / CH₂Cl₂ / 2 h / 22 °C

5: 85 percent / magnesium powder / tetrahydrofuran / 3 h / Ambient temperature

6: 93 percent / H₂, ClRh(Ph₃P)3 / benzene / 4 h / 23 °C

7: 83 percent / ZnBr₂ / CH₂Cl₂ / 2 h / 0 °C

8: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

9: 31 percent / NaIO₄ / acetone; H₂O / 1 h / 26 °C

With 1H-imidazole; sodium periodate; Wilkinson's catalyst; lithium aluminium tetrahydride; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; magnesium; pyridinium chlorochromate; zinc dibromide; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1246/bcsj.62.2618

Reference yield:

: 93223-61-1,114296-87-6,117557-98-9,124990-87-0
(S)-1-((4S,5R)-5-hydroxymethyl-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

: 124928-73-0
(4S,5R)-5-Ethyl-2,2,5-trimethyl-[1,3]dioxolane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / imidazole / dimethylformamide / 2.66 h / 24 °C

2: pyridinium chlorochromate, molecular sieves 3 Angstroem / CH₂Cl₂ / 2 h / 22 °C

3: 85 percent / magnesium powder / tetrahydrofuran / 3 h / Ambient temperature

4: 93 percent / H₂, ClRh(Ph₃P)3 / benzene / 4 h / 23 °C

5: 83 percent / ZnBr₂ / CH₂Cl₂ / 2 h / 0 °C

6: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 0 °C

7: 31 percent / NaIO₄ / acetone; H₂O / 1 h / 26 °C

With 1H-imidazole; sodium periodate; Wilkinson's catalyst; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; magnesium; pyridinium chlorochromate; zinc dibromide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1246/bcsj.62.2618