Technology Process of methyl (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoate
There total 11 articles about methyl (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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methyl (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-2,6,9,12,15,18,21-heptaenoate
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1312442-35-5
methyl (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoate
- Guidance literature:
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With
magnesium;
In
methanol;
at 0 - 20 ℃;
for 3.5h;
Inert atmosphere;
DOI:10.1007/s11745-011-3541-5
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68378-49-4
(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoic acid
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1312442-35-5
methyl (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoate
- Guidance literature:
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In
diethyl ether;
at 20 ℃;
for 0.0833333h;
DOI:10.1016/j.chemphyslip.2014.04.005
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1312442-35-5
methyl (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosa-6,9,12,15,18,21-hexaenoate
- Guidance literature:
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Multi-step reaction with 7 steps
1: pyridine / 2 h / 0 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 °C
3: formic acid / water; 1,4-dioxane / 1.5 h / 20 °C
4: sodium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran / 4 h / -85 - -30 °C / Inert atmosphere
5: formic acid / 1,4-dioxane / 1.5 h / 20 °C
6: sodium hexamethyldisilazane / tetrahydrofuran / Inert atmosphere
7: diethyl ether / 0.08 h / 20 °C
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; formic acid; sodium hexamethyldisilazane;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; water;
DOI:10.1016/j.chemphyslip.2014.04.005
