Technology Process of 3,3-Dimethyl-5-[5-(4-methyl-benzyl)-thiophen-2-yl]-pentanoic acid
There total 9 articles about 3,3-Dimethyl-5-[5-(4-methyl-benzyl)-thiophen-2-yl]-pentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NH2-NH2, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 15 min, 2.) room temp.
2: AlCl3 / nitrobenzene / 12 h / Ambient temperature
3: 1.) NH2-NH2, KOH, 2.) aq.HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.
With
hydrogenchloride; potassium hydroxide; aluminium trichloride; hydrazine;
In
nitrobenzene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: AlCl3 / nitrobenzene / 12 h / Ambient temperature
2: 1.) NH2-NH2, KOH, 2.) aq.HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.
With
hydrogenchloride; potassium hydroxide; aluminium trichloride; hydrazine;
In
nitrobenzene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) SOCl2, 2.) SnCl4 / 1.) 40 deg C, half an h., 2.) methylene chloride, -5 deg C to 5 deg C
2: 1.) NH2-NH2, KOH, 2.) aq. HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 15 min, 2.) room temp.
3: AlCl3 / nitrobenzene / 12 h / Ambient temperature
4: 1.) NH2-NH2, KOH, 2.) aq.HCl / 1.) triethylene glycol, from 96 deg C to 215 deg C, 30 min, 2.) room temp.
With
hydrogenchloride; potassium hydroxide; aluminium trichloride; thionyl chloride; tin(IV) chloride; hydrazine;
In
nitrobenzene;
