Methanone, phenyl[4-(1-piperidinyl)phenyl]-

Base Information

• Chemical Name: Methanone, phenyl[4-(1-piperidinyl)phenyl]-
• CAS No.: 106947-61-9
• Molecular Formula: C18H19NO
• Molecular Weight: 265.355
• DSSTox Substance ID: DTXSID30349919
• Nikkaji Number: J828.259E
• Wikidata: Q82125493
• Mol file: 106947-61-9.mol

Synonyms:Methanone, phenyl[4-(1-piperidinyl)phenyl]-;106947-61-9;CBMicro_008906;Oprea1_735822;SCHEMBL2742812;DTXSID30349919;SMSF0009186;STK764449;AKOS001627257;CB11944;BIM-0008902.P001;PHENYL(4-PIPERIDINOPHENYL)METHANONE;phenyl[4-(piperidin-1-yl)phenyl]methanone;EU-0073745;SR-01000452781;SR-01000452781-1

Chemical Property of Methanone, phenyl[4-(1-piperidinyl)phenyl]-

Chemical Property:

• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 265.146664230
• Heavy Atom Count: 20
• Complexity: 307

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=CC=C(C=C2)C(=O)C3=CC=CC=C3

Technology Process of Methanone, phenyl[4-(1-piperidinyl)phenyl]-

There total 5 articles about Methanone, phenyl[4-(1-piperidinyl)phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

piperidine (110-89-4) + 4-fluorobenzophenone (345-83-5) → phenyl-(4-piperidin-1-yl-phenyl)methanone (106947-61-9)

Guidance literature:

In dimethyl sulfoxide; at 70 - 80 ℃; for 30h;

DOI:10.1021/jo00385a012

Reference yield: 84.0%

piperidine (110-89-4) + 4-chlorobenzophenone (134-85-0) → phenyl-(4-piperidin-1-yl-phenyl)methanone (106947-61-9)

Guidance literature:

With magnesium hydroxide nanoparticles; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.cclet.2011.11.009

Reference yield: 62.0%

1,5-dibromo-pentane (111-24-0) + (4-aminophenyl)(phenyl)methanone (1137-41-3,444317-48-0) → phenyl-(4-piperidin-1-yl-phenyl)methanone (106947-61-9)

Guidance literature:

With potassium phosphate; In water; at 150 ℃; for 1.5h; under 9000.9 Torr; Sealed tube; Microwave irradiation;

DOI:10.1002/adsc.201500698

upstream raw materials:

piperidine

4-fluorobenzophenone

4-chlorobenzophenone

1,5-dibromo-pentane

Downstream raw materials:

3-(4-piperidinophenyl)-3-phenyl-6-morpholino-3H-naphtho[2,1-b]pyran

Phenyl-[4-(piperidin-1-yloxy)-phenyl]-methanone

1,1,2,2-tetraphenylethylene

4-diethylamino-4'-piperidinotriphenylmethanol