((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(R)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine

Base Information

Chemical Name:((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(R)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine
CAS No.:116227-54-4
Molecular Formula:C₃₀H₄₂N₂O₆
Molecular Weight:526.673
Hs Code.:

((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(R)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine

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Chemical Property of ((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(R)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine

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Technology Process of ((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(R)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine

There total 10 articles about ((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(R)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 90482-05-6
(S)-valinol t-butyl ether

: 116227-54-4
((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(S)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaOMe / methanol / 4 h / 0 °C

2: 60 percent / camphor sulphonic acid / toluene / 72 h / Heating

3: 1)t-butyllithium / 1) THF, -100 deg C, 0.3 h, 2) THF, -100 deg C, 0.3 h

With tert.-butyl lithium; sodium methylate; camphor-10-sulfonic acid; In methanol; toluene;
DOI:10.1016/S0040-4020(01)87686-9

Reference yield:

: 90482-05-6
(S)-valinol t-butyl ether

: 116227-54-4
((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(R)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / NaOMe / methanol / 4 h / 0 °C

2: 60 percent / camphor sulphonic acid / toluene / 72 h / Heating

3: 1)t-butyllithium / 1) THF, -100 deg C, 0.3 h, 2) THF, -100 deg C, 0.3 h

With tert.-butyl lithium; sodium methylate; camphor-10-sulfonic acid; In methanol; toluene;
DOI:10.1016/S0040-4020(01)87686-9

Reference yield:

: 90482-06-7
(S)-N,N-dimethyl-N'-(1-tert-butoxy-3-methyl-2-butyl)formamidine

: 116227-54-4
((S)-1-tert-Butoxymethyl-2-methyl-propyl)-[1-[(S)-5-(3,4-dimethoxy-benzyl)-9-methoxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-yl]-meth-(E)-ylidene]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / camphor sulphonic acid / toluene / 72 h / Heating

2: 1)t-butyllithium / 1) THF, -100 deg C, 0.3 h, 2) THF, -100 deg C, 0.3 h

With tert.-butyl lithium; camphor-10-sulfonic acid; In toluene;
DOI:10.1016/S0040-4020(01)87686-9