(3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester

Base Information

• Chemical Name: (3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester
• CAS No.: 88853-75-2
• Molecular Formula: C₄₈H₄₈ClN₃O₁₀
• Molecular Weight: 862.376
• Mol file: 88853-75-2.mol

Synonyms:

Chemical Property of (3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester

There total 2 articles about (3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-benzyl-N-<(3S,6S)-2-benzyloxycarbonyl-6-carboxy-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-L-threonine benzyl ester (88818-12-6) + diazodiphenylmethane (908093-98-1) → (3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester (88853-75-2) + N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester (88818-13-7)

Guidance literature:

In dichloromethane; chloroform; for 0.5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4020(01)88799-8

Reference yield:

(3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 2-benzyl ester (88818-12-6,88853-24-1) + diazodiphenylmethane (908093-98-1) → (3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 6-benzhydryl ester 2-benzyl ester (88853-75-2) + N-<(3S,6S)-6-benzhydryloxycarbonyl-2-benzyloxycarbonyl-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-O-benzyl-L-threonine benzyl ester (88818-13-7)

Guidance literature:

In dichloromethane; chloroform; for 0.5h; Yield given. Yields of byproduct given; Ambient temperature;

DOI:10.1016/S0040-4020(01)88799-8

upstream raw materials:

O-benzyl-N-<(3S,6S)-2-benzyloxycarbonyl-6-carboxy-6-<(chloroacetamido)methyl>perhydro-1,2-oxazine-3-carbonyl>-L-threonine benzyl ester

diazodiphenylmethane

(3R,6R)-3-((1S,2R)-2-Benzyloxy-1-benzyloxycarbonyl-propylcarbamoyl)-6-[(2-chloro-acetylamino)-methyl]-[1,2]oxazinane-2,6-dicarboxylic acid 2-benzyl ester