4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol

Base Information

Chemical Name:4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol
CAS No.:762275-98-9
Molecular Formula:C₁₃H₁₄N₂O₃
Molecular Weight:246.266
Hs Code.:

Synonyms:

Suppliers and Price of 4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol

There total 8 articles about 4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52249-86-2
2-benzyloxy-4-methoxyacetophenone

: 762275-98-9
4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol

Guidance literature:: Multi-step reaction with 9 steps

1.1: NBS; silica gel / CCl₄

2.1: MCPBA / CH₂Cl₂

3.1: imidazole / tetrahydrofuran

4.1: BuLi / tetrahydrofuran / -78 °C

4.2: B(OEt)3 / tetrahydrofuran

5.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

6.1: KF; aq. HBr

7.1: dibenzo-18-crown-6 / acetonitrile

8.1: HCO₂NH₄ / Pd(OH)2 / methanol / Heating

9.1: NH₂OH*HCl / ethanol; H₂O / Heating

With 1H-imidazole; potassium fluoride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzo-18-crown-6; n-butyllithium; hydroxylamine hydrochloride; hydrogen bromide; ammonium formate; silica gel; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile; 2.1: Baeyer-Villiger oxidation / 5.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: acetic acid 2-benzyloxy-5-bromo-4-methoxy-phenyl ester

: 762275-98-9
4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol

Guidance literature:: Multi-step reaction with 7 steps

1.1: imidazole / tetrahydrofuran

2.1: BuLi / tetrahydrofuran / -78 °C

2.2: B(OEt)3 / tetrahydrofuran

3.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

4.1: KF; aq. HBr

5.1: dibenzo-18-crown-6 / acetonitrile

6.1: HCO₂NH₄ / Pd(OH)2 / methanol / Heating

7.1: NH₂OH*HCl / ethanol; H₂O / Heating

With 1H-imidazole; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzo-18-crown-6; n-butyllithium; hydroxylamine hydrochloride; hydrogen bromide; ammonium formate; sodium carbonate; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; water; acetonitrile; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043

Reference yield:

: 762275-94-5
1-(2-benzyloxy-5-bromo-4-methoxy-phenyl)-ethanone

: 762275-98-9
4-(6-amino-pyridin-2-yl)-2,5-dimethoxy-phenol

Guidance literature:: Multi-step reaction with 8 steps

1.1: MCPBA / CH₂Cl₂

2.1: imidazole / tetrahydrofuran

3.1: BuLi / tetrahydrofuran / -78 °C

3.2: B(OEt)3 / tetrahydrofuran

4.1: Pd(PPh₃)4; aq. Na₂CO₃ / ethanol / 90 °C

5.1: KF; aq. HBr

6.1: dibenzo-18-crown-6 / acetonitrile

7.1: HCO₂NH₄ / Pd(OH)2 / methanol / Heating

8.1: NH₂OH*HCl / ethanol; H₂O / Heating

With 1H-imidazole; potassium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dibenzo-18-crown-6; n-butyllithium; hydroxylamine hydrochloride; hydrogen bromide; ammonium formate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium dihydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile; 1.1: Baeyer-Villiger oxidation / 4.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.06.043