Benzoic acid, 4-chloro-2-((2-methoxyphenyl)amino)-, ((4,5-dimethoxy-2-nitrophenyl)methylene)hydrazide

Base Information

• Chemical Name: Benzoic acid, 4-chloro-2-((2-methoxyphenyl)amino)-, ((4,5-dimethoxy-2-nitrophenyl)methylene)hydrazide
• CAS No.: 75423-01-7
• Molecular Formula: C₂₃H₂₁ClN₄O₆
• Molecular Weight: 484.896
• Mol file: 75423-01-7.mol

Synonyms:BRN 4610240;Benzoic acid, 4-chloro-2-((2-methoxyphenyl)amino)-, ((4,5-dimethoxy-2-nitrophenyl)methylene)hydrazide;75423-01-7;C23H21ClN4O6;C23-H21-Cl-N4-O6;LS-36518

Chemical Property of Benzoic acid, 4-chloro-2-((2-methoxyphenyl)amino)-, ((4,5-dimethoxy-2-nitrophenyl)methylene)hydrazide

Chemical Property:

• XLogP3: 5.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 8
• Exact Mass: 484.1149621
• Heavy Atom Count: 34
• Complexity: 707

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1NC2=C(C=CC(=C2)Cl)C(=O)NN=CC3=CC(=C(C=C3[N+](=O)[O-])OC)OC
• Isomeric SMILES: COC1=CC=CC=C1NC2=C(C=CC(=C2)Cl)C(=O)N/N=C/C3=CC(=C(C=C3[N+](=O)[O-])OC)OC

Technology Process of Benzoic acid, 4-chloro-2-((2-methoxyphenyl)amino)-, ((4,5-dimethoxy-2-nitrophenyl)methylene)hydrazide

There total 5 articles about Benzoic acid, 4-chloro-2-((2-methoxyphenyl)amino)-, ((4,5-dimethoxy-2-nitrophenyl)methylene)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4 dichlorobenzoic acid (50-84-0) → 4-Chloro-2-(2-methoxy-phenylamino)-benzoic acid [1-(4,5-dimethoxy-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide (75423-01-7)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃, copper powder / pentan-1-ol

2: SOCl₂ / 12 h / Heating

3: hydrazine hydrate / ethanol / 16 h / Heating

4: gl. acetic acid / ethanol / 4 h / Heating

With thionyl chloride; copper; potassium carbonate; hydrazine hydrate; acetic acid; In ethanol; pentan-1-ol;

Reference yield:

N-(2-Methoxyphenyl)-4-chloroanthranilic acid (32305-23-0) → 4-Chloro-2-(2-methoxy-phenylamino)-benzoic acid [1-(4,5-dimethoxy-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide (75423-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂ / 12 h / Heating

2: hydrazine hydrate / ethanol / 16 h / Heating

3: gl. acetic acid / ethanol / 4 h / Heating

With thionyl chloride; hydrazine hydrate; acetic acid; In ethanol;

Reference yield:

4-chloro-2-(2-methoxy-anilino)-benzoic acid methyl ester (23857-11-6) → 4-Chloro-2-(2-methoxy-phenylamino)-benzoic acid [1-(4,5-dimethoxy-2-nitro-phenyl)-meth-(E)-ylidene]-hydrazide (75423-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 16 h / Heating

2: gl. acetic acid / ethanol / 4 h / Heating

With hydrazine hydrate; acetic acid; In ethanol;

upstream raw materials:

6-nitroveratraldehyde

4-Chloro-2-(2-methoxy-phenylamino)-benzoic acid hydrazide

2,4 dichlorobenzoic acid

N-(2-Methoxyphenyl)-4-chloroanthranilic acid