N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt

Base Information

Chemical Name:N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt
CAS No.:918809-06-0
Molecular Formula:C₂HF₃O₂*C₃₃H₃₉N₅O₆S
Molecular Weight:747.793
Hs Code.:

N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt

Synonyms:

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Chemical Property of N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt

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Technology Process of N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt

There total 4 articles about N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1520082-82-9
C₄₃H₅₅N₅O₁₀S

: 76-05-1
trifluoroacetic acid

: 918809-06-0
N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt

Guidance literature:: C₄₃H₅₅N₅O₁₀S; With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate; at 20 ℃; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile; at 20 ℃;
DOI:10.1021/ml400453z

Reference yield:

: 745020-22-8
imidodicarbonic acid 2-(6-amino-1-isoquinolinyl)-1,3-bis(1,1-dimethylethyl)ester

: 918809-06-0
N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene; methanol / 20 - 60 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane / 20 °C / Inert atmosphere

3.2: 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml400453z

Reference yield:

: 900174-06-3
(3-ethoxy-4-isopropoxyphenyl)boronic acid

: 918809-06-0
N-(5-acetylamino-2-ethanesulfonylbenzyl)-2-(1-aminoisoquinolin-6-ylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetamide trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene; methanol / 20 - 60 °C / Inert atmosphere

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane / 20 °C / Inert atmosphere

3.2: 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml400453z