(4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid

Base Information

Chemical Name:(4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid
CAS No.:99463-57-7
Molecular Formula:C₃₀H₄₀O₉Si
Molecular Weight:572.728
Hs Code.:

(4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid

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Chemical Property of (4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid

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Technology Process of (4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid

There total 10 articles about (4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₅₀O₁₀Si₂

: 99463-57-7
(4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at -10 ℃; Yield given;
DOI:10.1016/S0040-4039(00)89274-6

Reference yield:

: 99463-56-6,99528-97-9
(2S,3S)-2-((4S,5R)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-3-hydroxy-3-(3,4,5-trimethoxy-phenyl)-propionic acid

: 99463-57-7
(4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid

Guidance literature:: With chloro-trimethyl-silane; methanesulfonyl chloride; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, -10 deg C, 30 min;
DOI:10.1016/S0040-4020(01)87656-0

Reference yield:

: 99463-47-5
((4R,5S)-4-Benzo[1,3]dioxol-5-yl-2,2-di-tert-butyl-[1,3,2]dioxasilinan-5-yl)-acetic acid

: 99463-57-7
(4aS,5S,6S,11bR)-2,2-Di-tert-butyl-6-(3,4,5-trimethoxy-phenyl)-4a,5,6,11b-tetrahydro-4H-1,3,8,10-tetraoxa-2-sila-cyclopenta[b]phenanthrene-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

2: 1.) LDA / 1.) THF, -78 deg C, 30 min; -40 deg C, 1 h, 2.) THF, -78 deg C, 3 min

3: 1.) TMSCl, NEt₃, 2.) MsCl, NEt₃ / 1.) CH₂Cl₂, 0 deg C, 15 min, 2.) CH₂Cl₂, -10 deg C, 30 min

With chloro-trimethyl-silane; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In dichloromethane;
DOI:10.1016/S0040-4020(01)87656-0