Technology Process of 2-Hydroxymethyl-3-phenylpyrazine
There total 7 articles about 2-Hydroxymethyl-3-phenylpyrazine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 66 percent / 20percent aq. HCl / 3 h / Heating
2: 62 percent / 90percent H2O2, maleic anhydride / CH2Cl2 / 48 h / Ambient temperature
3: 2) 10percent NaOH, methanol / 1.) reflux, 0.5 h 2.) reflux, 1 h
With
maleic anhydride; hydrogenchloride; methanol; sodium hydroxide; dihydrogen peroxide;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / 4 h / Heating
2: 66 percent / 20percent aq. HCl / 3 h / Heating
3: 62 percent / 90percent H2O2, maleic anhydride / CH2Cl2 / 48 h / Ambient temperature
4: 2) 10percent NaOH, methanol / 1.) reflux, 0.5 h 2.) reflux, 1 h
With
maleic anhydride; hydrogenchloride; methanol; sodium hydroxide; dihydrogen peroxide;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2) KOH / 1) ethanol, room temp. 1.5 h 2) reflux 5 h
2: 62 percent / 90percent H2O2, maleic anhydride / CH2Cl2 / 48 h / Ambient temperature
3: 2) 10percent NaOH, methanol / 1.) reflux, 0.5 h 2.) reflux, 1 h
With
maleic anhydride; methanol; potassium hydroxide; sodium hydroxide; dihydrogen peroxide;
In
dichloromethane;
