San B 8

Base Information

Chemical Name:San B 8
CAS No.:1414375-75-9
Molecular Formula:C₃₉H₄₆N₈O₆S₂
Molecular Weight:786.976
Hs Code.:

Synonyms:

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Chemical Property of San B 8

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Technology Process of San B 8

There total 3 articles about San B 8 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-tert-butyl 1-amino-3-phenyl-1-thioxopropan-2-ylcarbamate

: 1414375-75-9
San B 8

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 0.25 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: pyridine / 1,2-dimethoxyethane / 0.25 h / 0 °C / Inert atmosphere

2.2: 3 h / 0 °C / Inert atmosphere

2.3: 20 °C / Inert atmosphere

3.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: lithium hydroxide / ethanol / Inert atmosphere

8.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 1 h / 20 °C / Inert atmosphere

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / Inert atmosphere

With pyridine; potassium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; lithium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1021/jo3017499

Reference yield:

: C₁₉H₂₆N₂O₅S

: 1414375-75-9
San B 8

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / 1,2-dimethoxyethane / 0.25 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 °C / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: lithium hydroxide / ethanol / Inert atmosphere

7.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 1 h / 20 °C / Inert atmosphere

8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / Inert atmosphere

With pyridine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; lithium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1021/jo3017499

Reference yield:

: 256384-34-6
(R)-ethyl 2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]thiazole-4-carboxylate

: 1414375-75-9
San B 8

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

3: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C / Inert atmosphere

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 1 h / 20 °C / Inert atmosphere

5: lithium hydroxide / ethanol / Inert atmosphere

6: trifluoroacetic acid; methoxybenzene / dichloromethane / 1 h / 20 °C / Inert atmosphere

7: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / dichloromethane / Inert atmosphere

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; lithium hydroxide; In ethanol; dichloromethane;
DOI:10.1021/jo3017499