Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester

Base Information

• Chemical Name: Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester
• CAS No.: 171762-59-7
• Molecular Formula: C₄₃H₅₁N₃O₁₀Si
• Molecular Weight: 797.978
• Mol file: 171762-59-7.mol

Synonyms:

Chemical Property of Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester

There total 1 articles about Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-Amino-3'-tert-butyldiphenylsilyl-5'-deoxythymidine (146557-63-3) + Benzoic acid (3aR,5S,6R,6aR)-6-carboxymethyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester → Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester (171762-59-7)

Guidance literature:

With benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; Yield given. Multistep reaction; 1.) MeCN, THF, r.t., 1 h, 2.) r.t., 12 h;

Reference yield: 51.0%

thiophenol (108-98-5) + Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester (171762-59-7) → Benzoic acid (2S,3S,4R,5S)-3-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-4-hydroxy-5-phenylsulfanyl-tetrahydro-furan-2-ylmethyl ester (171762-56-4)

Guidance literature:

With trifluoroacetic acid; for 7h;

Reference yield:

Benzoic acid (3aR,5S,6R,6aR)-6-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-ylmethyl ester (171762-59-7) → C38H47N5O10Si (171762-49-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / TFA / 7 h

2: 82 percent / pyridine / 20 h / Ambient temperature

3: 96 percent / mCPBA / CH₂Cl₂ / -78 °C

4: 1.) bistrimethylsilylacetamide, TMSOTf, 2.) BF₃*Et₂O, / 1.) ClCH₂CH₂Cl, 90 deg C, 2 h, 2.) CHCl₃, r.t., 18 h

5: 78 percent / NaOMe / methanol / 3 h / Ambient temperature

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; sodium methylate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; dichloromethane;

upstream raw materials:

5'-Amino-3'-tert-butyldiphenylsilyl-5'-deoxythymidine

Downstream raw materials:

Benzoic acid (2S,3S,4R,5S)-3-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-4-hydroxy-5-phenylsulfanyl-tetrahydro-furan-2-ylmethyl ester

C₃₈H₄₇N₅O₁₀Si

Benzoic acid (2S,3R,4R,5S)-4-acetoxy-3-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-5-phenylsulfanyl-tetrahydro-furan-2-ylmethyl ester

Benzoic acid (2S,3R,4R,5S)-4-acetoxy-5-benzenesulfinyl-3-({[(2R,3S,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl]-carbamoyl}-methyl)-tetrahydro-furan-2-ylmethyl ester