N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

Base Information

Chemical Name:N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride
CAS No.:1228187-92-5
Molecular Formula:C₂₃H₂₇F₃N₄O₂*ClH
Molecular Weight:484.949
Hs Code.:

N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

Synonyms:

Suppliers and Price of N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

There total 8 articles about N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228187-98-1
N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine

: 1228187-92-5
N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; for 0.5h;

Reference yield:

: 1228188-09-7
phenylmethyl (1S,4S,6S)-4-formyl-3-azabicyclo[4,1,0]heptane-3-carboxylate

: 1228187-92-5
N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / dichloromethane / 4.5 h

1.2: 0 °C

1.3: 0.25 h

2.1: hydrogen / palladium on activated charcoal / methanol / 0.42 h

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

3.2: 1.5 h

4.1: hydrogenchloride / diethyl ether; dichloromethane / 0.5 h

With hydrogenchloride; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1228188-08-6
phenylmethyl (1S,4S,6S)-4-(hydroxymethyl)-3-azabicyclo[4,1,0]heptane-3-carboxylate

: 1228187-92-5
N-[((1S,4S,6S)-3-{[6-methyl-3-(propyloxy)-2-pyridinyl]carbonyl}-3-azabicyclo[4,1,0]hept-4-yl)methyl]-5-(trifluoromethyl)-2-pyridinamine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 20 °C

2.1: acetic acid / dichloromethane / 4.5 h

2.2: 0 °C

2.3: 0.25 h

3.1: hydrogen / palladium on activated charcoal / methanol / 0.42 h

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h

4.2: 1.5 h

5.1: hydrogenchloride / diethyl ether; dichloromethane / 0.5 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;