Technology Process of H-allo-Thr(tBu)-Phe-OTMSE
There total 5 articles about H-allo-Thr(tBu)-Phe-OTMSE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / 1,4-dioxane / 1 h / Inert atmosphere
2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / Cooling with ice; Inert atmosphere
3: hydrogen; palladium 10% on activated carbon / methanol / 4 h / Inert atmosphere
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/anie.201302266
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
methanol;
for 4h;
Inert atmosphere;
DOI:10.1002/anie.201302266
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1,2-dichloro-ethane; dmap / dichloromethane / 15 h / 0 - 20 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane / 1 h / Inert atmosphere
3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / Cooling with ice; Inert atmosphere
4: hydrogen; palladium 10% on activated carbon / methanol / 4 h / Inert atmosphere
With
hydrogenchloride; dmap; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; dichloromethane;
DOI:10.1002/anie.201302266
