Technology Process of Butanal, 2-methyl-3-(phenylmethoxy)-, (2R,3R)-
There total 7 articles about Butanal, 2-methyl-3-(phenylmethoxy)-, (2R,3R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,3R)-(-)-3-benzyloxy-2-methylbutan-1-ol;
With
oxalyl dichloride;
In
dichloromethane; dimethyl sulfoxide;
at -78 ℃;
for 0.166667h;
Schlenk technique;
Inert atmosphere;
With
triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at -78 - 0 ℃;
for 0.166667h;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/anie.201811330
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 70 percent / camphorsulphonic acid / methanol / 16 h / Ambient temperature
2: 1.) DMSO, oxalyl chloride; 2.) triethylamine / 1.) CH2Cl2, -60 deg C; 2.) CH2Cl2, room temp., 15 min.
With
oxalyl dichloride; camphor-10-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 80 percent / sodium hydride, terabutylammonium iodide / tetrahydrofuran / 1.) 1 h; 2.) reflux, 24 h
2: 70 percent / camphorsulphonic acid / methanol / 16 h / Ambient temperature
3: 1.) DMSO, oxalyl chloride; 2.) triethylamine / 1.) CH2Cl2, -60 deg C; 2.) CH2Cl2, room temp., 15 min.
With
oxalyl dichloride; camphor-10-sulfonic acid; tetra-(n-butyl)ammonium iodide; sodium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol;
