Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Base Information

• Chemical Name: Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
• CAS No.: 105395-11-7
• Molecular Formula: C₂₇H₃₈O₅S
• Molecular Weight: 474.662
• Mol file: 105395-11-7.mol

Synonyms:

Chemical Property of Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

There total 4 articles about Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-((5R,8R,9S,10S,13S,14S,17R)-3-Acetoxy-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-methylsulfanyl-5-oxo-pentanoic acid tert-butyl ester (105395-04-8,105395-05-9,105455-77-4,105455-78-5,113565-20-1,113565-28-9,113565-29-0,114029-97-9,125356-01-6,125356-02-7) → Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester (105395-11-7,105395-12-8,113504-18-0,113565-25-6)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 7h; Heating;

DOI:10.1016/S0040-4039(00)84555-4

Reference yield:

Acetic acid (5R,8R,9S,10S,13S,14S,17R)-17-(1-formyl-vinyl)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester (105395-03-7,115429-11-3) → Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester (105395-11-7,105395-12-8,113504-18-0,113565-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 58 percent / NEt₃ / dry ZnCl₂ / acetonitrile / 1.75 h / 20 °C

2: 96 percent / potassium fluoride / tetrahydrofuran; methanol

3: 83 percent / p-toluenesulfonic acid / benzene / 7 h / Heating

With potassium fluoride; toluene-4-sulfonic acid; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; acetonitrile; benzene;

DOI:10.1016/S0040-4039(00)84555-4

Reference yield:

Acetic acid (5R,8R,9S,10S,12S,13S,14S,17S)-17-(1-formyl-vinyl)-12-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester (80680-81-5,105395-02-6) → Acetic acid (5R,8R,9S,10S,13S,14S,17R)-10,13-dimethyl-17-(5-methylsulfanyl-6-oxo-5,6-dihydro-4H-pyran-3-yl)-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester (105395-11-7,105395-12-8,113504-18-0,113565-25-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / (COCl)2, DMSO / CH₂Cl₂ / 0.5 h / -55 °C

2: 58 percent / NEt₃ / dry ZnCl₂ / acetonitrile / 1.75 h / 20 °C

3: 96 percent / potassium fluoride / tetrahydrofuran; methanol

4: 83 percent / p-toluenesulfonic acid / benzene / 7 h / Heating

With potassium fluoride; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; benzene;

DOI:10.1016/S0040-4039(00)84555-4

upstream raw materials:

4-((5R,8R,9S,10S,13S,14S,17R)-3-Acetoxy-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-2-methylsulfanyl-5-oxo-pentanoic acid tert-butyl ester

Acetic acid (5R,8R,9S,10S,13S,14S,17R)-17-(1-formyl-vinyl)-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

(E)-4-((5R,8R,9S,10S,13S,14S,17R)-3-Acetoxy-10,13-dimethyl-12-oxo-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-5-(tert-butyl-dimethyl-silanyloxy)-2-methylsulfanyl-pent-4-enoic acid tert-butyl ester

Acetic acid (5R,8R,9S,10S,12S,13S,14S,17S)-17-(1-formyl-vinyl)-12-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester