Carbamic acid, [(1S)-1-[(4Z)-4,5-dihydro-5-oxo-4-(phenylmethylene)-2-oxazolyl]-3-meth ylbutyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [(1S)-1-[(4Z)-4,5-dihydro-5-oxo-4-(phenylmethylene)-2-oxazolyl]-3-meth ylbutyl]-, 1,1-dimethylethyl ester
CAS No.:107794-92-3
Molecular Formula:C20H26N2O4
Molecular Weight:358.437
Hs Code.:
Mol file:107794-92-3.mol

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Chemical Property of Carbamic acid, [(1S)-1-[(4Z)-4,5-dihydro-5-oxo-4-(phenylmethylene)-2-oxazolyl]-3-meth ylbutyl]-, 1,1-dimethylethyl ester

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Technology Process of Carbamic acid, [(1S)-1-[(4Z)-4,5-dihydro-5-oxo-4-(phenylmethylene)-2-oxazolyl]-3-meth ylbutyl]-, 1,1-dimethylethyl ester

There total 7 articles about Carbamic acid, [(1S)-1-[(4Z)-4,5-dihydro-5-oxo-4-(phenylmethylene)-2-oxazolyl]-3-meth ylbutyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 107694-12-2
Boc-L-Leu-DL-(β-OH)-Phe-OH

: 107794-92-3
Boc-Leu-Δ^Z-Phe azlactone

Guidance literature:: With sodium acetate; acetic anhydride; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(01)81745-2

Reference yield: 57.0%

: [(S)-1-(4-Benzyl-5-oxo-4,5-dihydro-oxazol-2-yl)-3-methyl-butyl]-carbamic acid tert-butyl ester

: 107794-92-3
Boc-Leu-Δ^Z-Phe azlactone

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,2-dimethoxyethane;
DOI:10.1016/0040-4039(95)00762-2

Reference yield:

: 80182-99-6
β-hydroxyphenylalanine methyl ester hydrochloride

: 107794-92-3
Boc-Leu-Δ^Z-Phe azlactone

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / HOBt; DCC; Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 1.9 g / aq. NaOH / methanol / 3 h / 20 °C

3: 1.2 g / NaOAc / acetic anhydride / 14 h / 20 °C

With sodium hydroxide; sodium acetate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In methanol; dichloromethane; acetic anhydride;
DOI:10.1002/anie.200460703