tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Base Information

Chemical Name:tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate
CAS No.:918309-35-0
Molecular Formula:C₃₆H₄₄N₆O₅S
Molecular Weight:672.849
Hs Code.:

tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Synonyms:

Suppliers and Price of tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

There total 6 articles about tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881997-05-3
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

: 918309-35-0
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1: 815 mg / Na₂CO₃ / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane; H₂O / 23 h / Heating

2: 649 mg / CBr₄; Ph₃P / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

3: 34.0 mg / tetrahydrofuran / 64 h / 0 - 20 °C

4: N,N-dimethylbarbituric acid / Pd(Ph₃P)4 / CH₂Cl₂ / 4 h / 20 °C

5: 129 mg / triethylamine / tetrahydrofuran / 36.5 h / 20 - 50 °C

With 1,3-dimethylbarbituric acid; carbon tetrabromide; sodium carbonate; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1: Suzuki cross-coupling;
DOI:10.1016/j.bmc.2006.08.037

Reference yield:

: 918309-14-5
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[4-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

: 918309-35-0
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 649 mg / CBr₄; Ph₃P / CH₂Cl₂; tetrahydrofuran / 0.5 h / 0 °C

2: 34.0 mg / tetrahydrofuran / 64 h / 0 - 20 °C

3: N,N-dimethylbarbituric acid / Pd(Ph₃P)4 / CH₂Cl₂ / 4 h / 20 °C

4: 129 mg / triethylamine / tetrahydrofuran / 36.5 h / 20 - 50 °C

With 1,3-dimethylbarbituric acid; carbon tetrabromide; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2006.08.037

Reference yield:

: 918309-29-2
tert-butyl (2E)-3-(2-[4-(bromomethyl)phenyl]-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

: 918309-35-0
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-(4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: 34.0 mg / tetrahydrofuran / 64 h / 0 - 20 °C

2: N,N-dimethylbarbituric acid / Pd(Ph₃P)4 / CH₂Cl₂ / 4 h / 20 °C

3: 129 mg / triethylamine / tetrahydrofuran / 36.5 h / 20 - 50 °C

With 1,3-dimethylbarbituric acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2006.08.037