(R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Base Information

Chemical Name:(R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide
CAS No.:1091682-38-0
Molecular Formula:C₃₀H₄₇N₅O₅
Molecular Weight:557.734
Hs Code.:

(R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Chemical Property:

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Technology Process of (R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

There total 7 articles about (R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₅H₅₉N₅O₇

: 1091682-38-0
(R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃;
DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

: 122-85-0
para-acetamidobenzaldehyde

: 1091682-38-0
(R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

2: sodium hydroxide / water; tetrahydrofuran / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: hydrogenchloride / water; ethyl acetate / 20 °C

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

7: hydrogen; palladium on activated charcoal / ethanol / 20 °C

With hydrogenchloride; dmap; palladium on activated charcoal; hydrogen; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

: C₂₂H₂₇N₃O₃*ClH

: 1091682-38-0
(R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: hydrogenchloride / water; ethyl acetate / 20 °C

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

4: hydrogen; palladium on activated charcoal / ethanol / 20 °C

With hydrogenchloride; dmap; palladium on activated charcoal; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmcl.2016.04.086