2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

Base Information

Chemical Name:2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid
CAS No.:937060-87-2
Molecular Formula:C₃₁H₃₅ClN₄O₆
Molecular Weight:595.095
Hs Code.:

2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

Synonyms:

Suppliers and Price of 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

There total 9 articles about 2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 937057-69-7
2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethanol

: 937060-87-2
2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 3 h / 0 °C

2.1: sodium azide / water; N,N-dimethyl-formamide / 6 h / 80 °C

3.1: toluene / Reflux

4.1: sodium hydroxide / tetrahydrofuran; methanol; water / 80 °C

4.2: Amberlite IR-120B resin

With sodium azide; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-48-2
[5-chloro-2-(1H-pyrrol-1-yl)phenyl](2,3-dimethoxyphenyl)methanone

: 937060-87-2
2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: trichlorophosphate / 20 °C / Cooling with ice

1.2: 3 h / 50 °C

2.1: toluene / 7 h / 100 °C

3.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

5.1: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

8.1: sodium azide / water; N,N-dimethyl-formamide / 6 h / 80 °C

9.1: toluene / Reflux

10.1: sodium hydroxide / tetrahydrofuran; methanol; water / 80 °C

10.2: Amberlite IR-120B resin

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; triethylamine; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1.1: Vilsmeier reaction / 1.2: Vilsmeier reaction / 2.1: Wittig reaction / 4.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054

Reference yield:

: 937057-49-3
1-[4-chloro-2-(2,3-dimethoxybenzoyl)phenyl]-1H-pyrrole-2-carbaldehyde

: 937060-87-2
2-[(1-{2-[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1H-1,2,3-triazol-4-yl)methoxy]-2-ethylbutanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene / 7 h / 100 °C

2.1: sodium tetrahydroborate / methanol / 1 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 8 h / 20 °C

4.1: CHIRALCEL OD column / hexane; isopropyl alcohol / Resolution of racemate

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

6.1: triethylamine / dichloromethane / 3 h / 0 °C

7.1: sodium azide / water; N,N-dimethyl-formamide / 6 h / 80 °C

8.1: toluene / Reflux

9.1: sodium hydroxide / tetrahydrofuran; methanol; water / 80 °C

9.2: Amberlite IR-120B resin

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; 1.1: Wittig reaction / 3.1: Michael reaction;
DOI:10.1016/j.bmc.2012.02.054