C₁₄H₁₇NO₃

Base Information

• Chemical Name: C₁₄H₁₇NO₃
• CAS No.: 1438888-30-2
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.294
• Mol file: 1438888-30-2.mol

Synonyms:

Chemical Property of C₁₄H₁₇NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₇NO₃

There total 3 articles about C₁₄H₁₇NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-propionaldehyde (104-53-0) + C17H18NO6P (1438888-27-7) → C14H17NO3 + C14H17NO3 (1438888-30-2)

Guidance literature:

C₁₇H₁₈NO₆P; With magnesium bromide ethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

3-phenyl-propionaldehyde; In tetrahydrofuran; at 20 ℃; for 17h; Overall yield = 95 %; stereoselective reaction; Inert atmosphere;

DOI:10.1002/ejoc.201300112

Reference yield:

N-benzyloxycarbonyl-α-(diphenylphosphono)glycine methyl ester (1191124-96-5) → C14H17NO3 (1438888-30-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 4 h / 0 - 20 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 17 h / 0 - 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; magnesium bromide ethyl etherate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 17 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; palladium 10% on activated carbon; hydrogen; magnesium bromide ethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201300112

Reference yield:

C15H16NO5P*ClH → C14H17NO3 (1438888-30-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 17 h / 0 - 20 °C / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; magnesium bromide ethyl etherate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 17 h / 20 °C / Inert atmosphere

With dmap; magnesium bromide ethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201300112

upstream raw materials:

N-benzyloxycarbonyl-α-(diphenylphosphono)glycine methyl ester

3-phenyl-propionaldehyde

C₁₇H₁₈NO₆P