Technology Process of C33H40FN3O3
There total 7 articles about C33H40FN3O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-piperidinylcarbonyl chloride; (3R,3aS,4S,4aR,7R,8aS,9aR)-7-(aminomethyl)-4-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-3-methyldecahydronaphtho[2,3-c]furan-1(3H)-one;
With
triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
With
trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/ml400452v
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / dichloromethane / 2 h / -40 - 20 °C
2: sodium azide / dimethyl sulfoxide / 1.5 h / 20 - 65 °C
3: trimethylphosphane / tetrahydrofuran; water; ethyl acetate / 4 h / 0 - 20 °C
4: triethylamine / dichloromethane / 0 - 20 °C
With
sodium azide; triethylamine; trimethylphosphane;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ml400452v
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C
1.2: 1 h / 20 °C
2.1: hydrogenchloride / water; 1,4-dioxane / 1 h
3.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.08 h / 0 °C
4.1: triethylamine / dichloromethane / 2 h / -40 - 20 °C
5.1: sodium azide / dimethyl sulfoxide / 1.5 h / 20 - 65 °C
6.1: trimethylphosphane / tetrahydrofuran; water; ethyl acetate / 4 h / 0 - 20 °C
7.1: triethylamine / dichloromethane / 0 - 20 °C
With
hydrogenchloride; sodium tetrahydroborate; sodium azide; potassium tert-butylate; triethylamine; trimethylphosphane;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;
1.1: |Wittig Olefination / 1.2: |Wittig Olefination;
DOI:10.1021/ml400452v
