4H,5H,6H-cyclopenta[b]thiophen-4-amine

Base Information

• Chemical Name: 4H,5H,6H-cyclopenta[b]thiophen-4-amine
• CAS No.: 108046-24-8
• Molecular Formula: C7H9NS
• Molecular Weight: 139.21800
• Hs Code.: 2934999090
• Mol file: 108046-24-8.mol

Synonyms:

Chemical Property of 4H,5H,6H-cyclopenta[b]thiophen-4-amine

Chemical Property:

• PSA: 54.26000
• LogP: 2.39440

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dihydro-4H-cyclopenta[b]thiophen-4-ylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H,5H,6H-cyclopenta[b]thiophen-4-amine

There total 7 articles about 4H,5H,6H-cyclopenta[b]thiophen-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6-dihydrocyclopenta[b]thiophen-4-one oxime (343929-41-9) → 5,6-dihydro-4H-cyclopenta[b]thiophen-4-ylamine (108046-24-8)

Guidance literature:

In tetrahydrofuran;

Reference yield:

3-amino-3-(thien-3-yl)propanoic acid (94333-62-7,3310-99-4) → 5,6-dihydro-4H-cyclopenta[b]thiophen-4-ylamine (108046-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1: TFA-anhydride / 1 h at room temperature then 3 h reflux

With trifluoroacetic anhydride;

DOI:10.1016/S0040-4039(00)84596-7

Reference yield:

2,2,2-trifluoro-N-(5,6-dihydro-6-oxo-4H-cyclopenta[b]thiophen-4-yl)acetamide (108046-14-6) → 5,6-dihydro-4H-cyclopenta[b]thiophen-4-ylamine (108046-24-8)

Guidance literature:

DOI:10.1016/S0040-4039(00)84596-7

upstream raw materials:

2,2,2-trifluoro-N-(5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)acetamide

2,2,2-trifluoro-N-(5,6-dihydro-6-oxo-4H-cyclopenta[b]thiophen-4-yl)acetamide

3-amino-3-(thien-3-yl)propanoic acid

(+/-)-2,2,2-trifluoro-N-(cis-5,6-dihydro-6-hydroxy-4H-cyclopenta[b]thiophen-4-yl)acetamide

Downstream raw materials:

(5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)tritylamine