Cycloheptanone, 3-(1-methylethyl)-

Base Information

• Chemical Name: Cycloheptanone, 3-(1-methylethyl)-
• CAS No.: 108168-72-5
• Molecular Formula: C10H18O
• Molecular Weight: 154.252
• Mol file: 108168-72-5.mol

Synonyms:

Chemical Property of Cycloheptanone, 3-(1-methylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cycloheptanone, 3-(1-methylethyl)-

There total 7 articles about Cycloheptanone, 3-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-Cyclohepten-1-one (1121-66-0) + isopropylmagnesium chloride (1068-55-9) → 3-isopropylcycloheptanone (108168-72-5,154701-69-6)

Guidance literature:

With copper(l) iodide; (4-(S)-isopropyl-2-Ph-oxazoline-2'-Se)2; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -45 ℃;

DOI:10.1016/S0040-4039(02)01713-6

Reference yield:

1-methoxycyclohepta-1,3,5-triene (1728-32-1) → 3-isopropylcycloheptanone (108168-72-5,154701-69-6)

Guidance literature:

Multi-step reaction with 3 steps

2: 10percent aq. H₂SO₄

3: H₂ / 5percent Pd/C

With sulfuric acid; hydrogen; palladium on activated charcoal;

DOI:10.1016/S0040-4039(00)74485-6

Reference yield:

3-methoxy-1,3,5-cycloheptatriene (1714-40-5) → 3-isopropylcycloheptanone (108168-72-5,154701-69-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₄NOTs / dimethylformamide / electroreduction

2: 10percent aq. H₂SO₄

3: H₂ / 5percent Pd/C

With sulfuric acid; hydrogen; tetraethylammonium tosylate; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)74485-6

upstream raw materials:

1-Aminomethyl-2-isopropyl-cyclohexanol

2-Cyclohepten-1-one

isopropylmagnesium chloride

3-methoxy-1,3,5-cycloheptatriene

Downstream raw materials:

hinokitiol

Refernces

• 1、 Shono, Tatsuya,Nozoe, Tetsuo,Yamaguchi, Yoshihide,Ishifune, Manabu,Sakaguchi, Masashi,et al.. "A NOVEL ELECTROREDUCTIVE ALKYLATION OF CYCLOHEPTATRIENE SYSTEMS AND ITS APPLICATION TO FACILE SYNTHESIS OF β-THUJAPLICIN". . p. 1051 - 1054. Retrieved 1991.