Technology Process of methyl 2-acetamido-4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside
There total 8 articles about methyl 2-acetamido-4-O-(2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl)-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / p-toluenesulphonic acid / acetonitrile
2: 86 percent / sodium hydride / 1,2-dimethoxy-ethane
3: 95 percent / molecular sieves, sodium cyanoborohydride, HCl / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
4: 46 percent / collidine, silver triflate / nitromethane / 1.) -25 deg C, 4 h; 2.) rt, overnight
5: 1.) hydrazine hydrate / 1.) 95percent aqueous ethanol, reflux, 30 min; 2.) pyridine, rt, overnight
With
2,3,5-trimethyl-pyridine; hydrogenchloride; molecular sieve; silver trifluoromethanesulfonate; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; hydrazine hydrate;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; nitromethane; acetonitrile;
DOI:10.1139/v85-182
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / p-toluenesulphonic acid / acetonitrile
2: 86 percent / sodium hydride / 1,2-dimethoxy-ethane
3: 95 percent / molecular sieves, sodium cyanoborohydride, HCl / tetrahydrofuran; diethyl ether / 1 h / Ambient temperature
4: 46 percent / collidine, silver triflate / nitromethane / 1.) -25 deg C, 4 h; 2.) rt, overnight
5: 1.) hydrazine hydrate / 1.) 95percent aqueous ethanol, reflux, 30 min; 2.) pyridine, rt, overnight
With
2,3,5-trimethyl-pyridine; hydrogenchloride; molecular sieve; silver trifluoromethanesulfonate; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; hydrazine hydrate;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; nitromethane; acetonitrile;
DOI:10.1139/v85-182
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 46 percent / collidine, silver triflate / nitromethane / 1.) -25 deg C, 4 h; 2.) rt, overnight
2: 1.) hydrazine hydrate / 1.) 95percent aqueous ethanol, reflux, 30 min; 2.) pyridine, rt, overnight
With
2,3,5-trimethyl-pyridine; silver trifluoromethanesulfonate; hydrazine hydrate;
In
nitromethane;
DOI:10.1139/v85-182
