2-Amino-4-chloro-5-fluorobenzoic acid

Base Information

Chemical Name:2-Amino-4-chloro-5-fluorobenzoic acid
CAS No.:108288-16-0
Molecular Formula:C7H5ClFNO2
Molecular Weight:189.574
Hs Code.:2922499990
DSSTox Substance ID:DTXSID70562807
Wikidata:Q82447088
Mol file:108288-16-0.mol

Synonyms:2-Amino-4-chloro-5-fluorobenzoic acid;108288-16-0;2-amino-4-chloro-5-fluoro-benzoic acid;Benzoic acid, 2-amino-4-chloro-5-fluoro-;BENZOIC ACID,2-AMINO-4-CHLORO-5-FLUORO-;SCHEMBL1096218;DTXSID70562807;4-chloro-5-fluoroanthranilic acid;CL9060;MFCD05664859;2-Amino-4-chloro-5-fluorobenzoicacid;AKOS006292975;AM83212;CS-W005711;SB30520;DS-15621;SY002460;A848156;2-amino-4-chloro-5-fluorobenzoic acid, AldrichCPR

Suppliers and Price of 2-Amino-4-chloro-5-fluorobenzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Amino-4-chloro-5-fluorobenzoicacid
1g
$ 1175.00

SynQuest Laboratories
2-Amino-4-chloro-5-fluorobenzoic acid 97%
1 g
$ 934.00

SynQuest Laboratories
2-Amino-4-chloro-5-fluorobenzoic acid 97%
250 mg
$ 343.00

J&W Pharmlab
2-Amino-4-chloro-5-fluoro-benzoicacid 97%
1g
$ 88.00

Crysdot
2-Amino-4-chloro-5-fluorobenzoicacid 98%
5g
$ 267.00

Crysdot
2-Amino-4-chloro-5-fluorobenzoicacid 98%
10g
$ 446.00

ChemScene
2-Amino-4-chloro-5-fluorobenzoicacid 98.06%
5g
$ 212.00

ChemScene
2-Amino-4-chloro-5-fluorobenzoicacid 98.06%
10g
$ 354.00

ChemScene
2-Amino-4-chloro-5-fluorobenzoicacid 98.06%
1g
$ 71.00

Chemenu
2-Amino-4-chloro-5-fluoro-benzoicacid 95+%
5g
$ 252.00

Total 27 raw suppliers

Chemical Property of 2-Amino-4-chloro-5-fluorobenzoic acid

Chemical Property:

Boiling Point:350.096 °C at 760 mmHg
PKA:4.37±0.10(Predicted)
Flash Point:165.533 °C
PSA：63.32000
Density:1.574 g/cm³
LogP:2.34070
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:188.9992843
Heavy Atom Count:12
Complexity:190

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-4-chloro-5-fluorobenzoicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=CC(=C1F)Cl)N)C(=O)O
Uses 2-Amino-4-chloro-5-fluorobenzoic acid is used to synthesize 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization.

Technology Process of 2-Amino-4-chloro-5-fluorobenzoic acid

There total 3 articles about 2-Amino-4-chloro-5-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108288-15-9
N-(3-Chloro-4-fluorophenyl)-2-(hydroxyimino)acetamide

: 108288-16-0
2-amino-4-chloro-5-fluoro-benzoic acid

Guidance literature:: With sodium hydroxide; sulfuric acid; dihydrogen peroxide; Yield given. Multistep reaction; 1.) 80 deg C, 60 min, 2.) 80-90 deg C, 2 h;;
DOI:10.1002/jhet.5570230640

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 108288-16-0
2-amino-4-chloro-5-fluoro-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) conc. HCl, NH₂OH*HCl, 2.) Na₂SO₄*10 H₂O; / 1.) water, 2.) 90-95 deg C, 20 min, 3.) reflux 3 h;

2: 1.) H₂SO₄, 2.) 2.5 N NaOH, 30percent H₂O₂; / 1.) 80 deg C, 60 min, 2.) 80-90 deg C, 2 h;

With hydrogenchloride; sodium hydroxide; sulfuric acid; hydroxylamine hydrochloride; dihydrogen peroxide; sodium sulfate;
DOI:10.1002/jhet.5570230640