16-carbomethoxy-16-vindolinyl-N^b-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine

Base Information

• Chemical Name: 16-carbomethoxy-16-vindolinyl-N^b-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine
• CAS No.: 109748-83-6
• Molecular Formula: C₅₈H₆₈N₄O₁₁S
• Molecular Weight: 1029.26
• Mol file: 109748-83-6.mol

Synonyms:

Chemical Property of 16-carbomethoxy-16-vindolinyl-N^b-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 16-carbomethoxy-16-vindolinyl-N^b-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine

There total 22 articles about 16-carbomethoxy-16-vindolinyl-N^b-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

C58H66N4O11S (109740-20-7,109785-59-3,126643-73-0) → 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In acetone; for 0.166667h;

DOI:10.1021/jo00228a035

Reference yield: 33.0%

C58H66N4O11S (109740-20-7,109785-59-3,126643-73-0) → 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In acetone; for 0.166667h;

DOI:10.1021/jo00228a035

Reference yield: 33.0%

C58H66N4O11S (109740-20-7,109785-59-3,126643-73-0) → 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2) + 16-carbomethoxy-16-vindolinyl-Nb-benzyl-20-<3-(p-toluenesulfonyloxy)propyl>-D-norcleavamine (109748-83-6,109836-18-2)

Guidance literature:

With sodium tetrahydroborate; acetic acid; In acetone; for 0.166667h;

DOI:10.1021/jo00228a035

upstream raw materials:

(Z)-7-Benzyl-4b-chloro-9-[3-(toluene-4-sulfonyloxy)-propyl]-4b,5,6,7,8,9,10,12-octahydro-7,12-diaza-cyclonona[a]indene-11-carboxylic acid methyl ester

vindoline hydrochloride

methyl 3-benzyl-1,2,3,4,5,6,7,8-octahydro-5(3-p-toluenesulfonyloxypropyl)azonino (6,7-b)indole-7-carboxylate

C₅₈H₆₆N₄O₁₁S

Downstream raw materials:

C₅₁H₆₁N₄O₈⁽¹⁺⁾*C₇H₇O₃S^(1-)

C₅₁H₆₁N₄O₈⁽¹⁺⁾*C₇H₇O₃S^(1-)

C₅₁H₆₁N₄O₈⁽¹⁺⁾*C₇H₇O₃S^(1-)

C₅₁H₆₁N₄O₈⁽¹⁺⁾*C₇H₇O₃S^(1-)