(R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide

Base Information

Chemical Name:(R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide
CAS No.:1264520-57-1
Molecular Formula:C₃₆H₄₆F₆N₃O₂PSSi
Molecular Weight:757.896
Hs Code.:

(R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide

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Chemical Property of (R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide

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Technology Process of (R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide

There total 4 articles about (R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 1264520-57-1
(R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 20 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 1 h / 0 °C / Inert atmosphere

With triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja1106282

Reference yield:

: C₂₆H₃₇N₂O₄P

: 1264520-57-1
(R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: dichloromethane / 1 h / 0 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja1106282

Reference yield:

: 1264520-48-0
tert-butyl (R)-1-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-ylamino]-3-methyl-1-oxobutan-2-ylcarbamate

: 1264520-57-1
(R)-2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N-[(2S,3R)-3-(tert-butyldimethylsilyloxy)-1-(diphenylphosphino)-butan-2-yl]-3-methylbutanamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: dichloromethane / 1 h / 0 °C / Inert atmosphere

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja1106282