Technology Process of 2'-(AMINOMETHYL)-BIPHENYL-4-METHANOL
There total 7 articles about 2'-(AMINOMETHYL)-BIPHENYL-4-METHANOL which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent Chromat. / imidazole / dimethylformamide / 2.5 h / 22 °C
2: n-butyllithium / tetrahydrofuran; toluene; hexane / 2.5 h / -78 °C
3: 1.29 kg / HCl / ethyl acetate; H2O / 1 h / -4 - 3 °C
4: sodium carbonate; triphenylphosphine; palladium(II) acetate / H2O; tetrahydrofuran / 3.5 h / Heating
5: 97 percent / sodium acetate trihydrate; hydroxylamine hydrochloride / ethanol; H2O / 4 h / 0 °C
6: 5.72 kg / NH3; H2 / Pd/C / methanol / 1.5 h / 22 °C / 7757.22 Torr
7: 2.9 kg / HCl / ethyl acetate; H2O / 0.5 h / 20 °C
With
1H-imidazole; hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; palladium diacetate; sodium carbonate; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
4: Suzuki coupling;
DOI:10.1016/j.tetasy.2003.09.022
- Guidance literature:
-
Multi-step reaction with 6 steps
1: n-butyllithium / tetrahydrofuran; toluene; hexane / 2.5 h / -78 °C
2: 1.29 kg / HCl / ethyl acetate; H2O / 1 h / -4 - 3 °C
3: sodium carbonate; triphenylphosphine; palladium(II) acetate / H2O; tetrahydrofuran / 3.5 h / Heating
4: 97 percent / sodium acetate trihydrate; hydroxylamine hydrochloride / ethanol; H2O / 4 h / 0 °C
5: 5.72 kg / NH3; H2 / Pd/C / methanol / 1.5 h / 22 °C / 7757.22 Torr
6: 2.9 kg / HCl / ethyl acetate; H2O / 0.5 h / 20 °C
With
hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; palladium diacetate; sodium carbonate; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; hexane; water; ethyl acetate; toluene;
3: Suzuki coupling;
DOI:10.1016/j.tetasy.2003.09.022