(2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:148064-68-0
Molecular Formula:C₃₅H₅₂N₄O₅Si
Molecular Weight:636.907
Hs Code.:

(2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Synonyms:

Suppliers and Price of (2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

There total 17 articles about (2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1466-67-7
1,3-dibenzylurea

: 148064-68-0
(2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 16 steps

1: 2) ethyl acetate, reflux

2: LiBH₄ / diethyl ether

3: Zn(N₃)2(py)2, Ph₃P, DEAD, imid / toluene

4: H₂ / 10percent Pd/C / ethanol

5: pyridine / CH₂Cl₂

6: TBAF / tetrahydrofuran / 0 to 25 deg C

7: (COCl)2, DMSO, DIPEA / CH₂Cl₂

8: BF₃*Et₂O / CH₂Cl₂ / -78 - -20 °C

9: DIPEA / CH₂Cl₂ / 0 °C

10: OsO₄, NMO / acetone; butan-1-ol; H₂O

11: NaIO₄ / tetrahydrofuran; H₂O

12: toluene / 70 °C

13: 85 percent / 8.8 eq. NaBH₄ / methanol

14: DIPEA / CH₂Cl₂

15: LiBH₄ / tetrahydrofuran / Heating

16: (COCl)2, DMSO, DIPEA / CH₂Cl₂

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; oxalyl dichloride; Zn(N₃)2/bis-pyridine complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetone; toluene; butan-1-ol;
DOI:10.1021/jo00062a003

Reference yield:

: 148064-50-0
1,3-Dibenzyl-5-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-ethyl]-[1,3,5]triazinan-2-one

: 148064-68-0
(2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 14 steps

1: Zn(N₃)2(py)2, Ph₃P, DEAD, imid / toluene

2: H₂ / 10percent Pd/C / ethanol

3: pyridine / CH₂Cl₂

4: TBAF / tetrahydrofuran / 0 to 25 deg C

5: (COCl)2, DMSO, DIPEA / CH₂Cl₂

6: BF₃*Et₂O / CH₂Cl₂ / -78 - -20 °C

7: DIPEA / CH₂Cl₂ / 0 °C

8: OsO₄, NMO / acetone; butan-1-ol; H₂O

9: NaIO₄ / tetrahydrofuran; H₂O

10: toluene / 70 °C

11: 85 percent / 8.8 eq. NaBH₄ / methanol

12: DIPEA / CH₂Cl₂

13: LiBH₄ / tetrahydrofuran / Heating

14: (COCl)2, DMSO, DIPEA / CH₂Cl₂

With pyridine; 1H-imidazole; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; oxalyl dichloride; Zn(N₃)2/bis-pyridine complex; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; toluene; butan-1-ol;
DOI:10.1021/jo00062a003

Reference yield:

: 148064-51-1
5-[(S)-1-Azidomethyl-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1,3-dibenzyl-[1,3,5]triazinan-2-one

: 148064-68-0
(2S,4R,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(3,5-dibenzyl-4-oxo-[1,3,5]triazinan-1-yl)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: H₂ / 10percent Pd/C / ethanol

2: pyridine / CH₂Cl₂

3: TBAF / tetrahydrofuran / 0 to 25 deg C

4: (COCl)2, DMSO, DIPEA / CH₂Cl₂

5: BF₃*Et₂O / CH₂Cl₂ / -78 - -20 °C

6: DIPEA / CH₂Cl₂ / 0 °C

7: OsO₄, NMO / acetone; butan-1-ol; H₂O

8: NaIO₄ / tetrahydrofuran; H₂O

9: toluene / 70 °C

10: 85 percent / 8.8 eq. NaBH₄ / methanol

11: DIPEA / CH₂Cl₂

12: LiBH₄ / tetrahydrofuran / Heating

13: (COCl)2, DMSO, DIPEA / CH₂Cl₂

With pyridine; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; oxalyl dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; toluene; butan-1-ol;
DOI:10.1021/jo00062a003