C₃₀H₃₆N₂O₄Se

Base Information

• Chemical Name: C₃₀H₃₆N₂O₄Se
• CAS No.: 118378-11-3
• Molecular Formula: C₃₀H₃₆N₂O₄Se
• Molecular Weight: 567.587
• Mol file: 118378-11-3.mol

Synonyms:

Chemical Property of C₃₀H₃₆N₂O₄Se

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₆N₂O₄Se

There total 19 articles about C₃₀H₃₆N₂O₄Se which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ortho-nitrophenyl selenocyanate (51694-22-5) + C24H33NO3 (118378-10-2,118456-62-5,124752-83-6,124752-85-8) → C30H36N2O4Se (118378-11-3,118455-80-4,124752-84-7)

Guidance literature:

With tributylphosphine; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1016/S0040-4020(01)83440-2

Reference yield:

(1R,2S,6S,7S)-2-Benzyloxymethyl-5-oxo-bicyclo[4.2.0]octane-7-carboxylic acid methyl ester (124665-33-4) → C30H36N2O4Se (118378-11-3,118455-80-4,124752-84-7)

Guidance literature:

Multi-step reaction with 17 steps

1: amberlyst 15 / 2 h / 0 °C

2: benzene; diethyl ether / 0.58 h

3: pyridinium p-toluenesulfonate / acetone / 0.33 h / Ambient temperature

4: 84 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 46 h / Ambient temperature

5: sodium hydride / tetrahydrofuran / 6.5 h / Ambient temperature

6: triethylamine / 1.) 0 deg C, 1h; 2.) rt, 36h

7: potassium hydroxide / methanol; H₂O / 2.5 h / Heating

8: 87 percent / hydroxylamine hydrochloride, sodium acetate / methanol / 0.67 h / Heating

9: xylene / 0.83 h / 150 °C

10: sodium hydroxide / ethanol; H₂O / 7.25 h / Heating

11: 84 percent / H₂, (1S)-(+)-10-camphorsulfonic acid / palladium hydroxide on carbon / ethyl acetate / 22.5 h

12: 85 percent / N-ethyldiisopropylamine / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 0 deg C, 40 min; 2.) rt,1.33 h

13: lithium diisopropylamide / hexane; tetrahydrofuran / 1.) 0 deg C, 50 min; 2.) rt, 50 min

14: 83 percent / n-BuLi / hexane; tetrahydrofuran / 1.1 h / Ambient temperature

15: 71 percent / dicyclohexylcarbodiimide, pyridine, trifluoroacetic acid, DMSO / benzene / 4.5 h / Ambient temperature

16: 69 percent / camphorsulfonic acid / 2.5 h / Ambient temperature

17: 83 percent / tri-n-butylphosphine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; n-butyllithium; Amberlyst 15; tributylphosphine; camphor-10-sulfonic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; pyridinium p-toluenesulfonate; sodium hydride; dimethyl sulfoxide; (+)-10-camphorsulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium diisopropyl amide; dmap; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate; acetone; xylene; benzene;

DOI:10.1016/S0040-4020(01)83440-2

Reference yield:

(1R,2aR,3R,4aS,8bR)-3-Benzyloxymethyl-1-(1-methoxymethoxy-1-methyl-ethyl)-8-methyl-1,2,2a,3,4,5,6,8b-octahydro-4aH-cyclobuta[a]naphthalen-7-one oxime (124665-34-5) → C30H36N2O4Se (118378-11-3,118455-80-4,124752-84-7)

Guidance literature:

Multi-step reaction with 9 steps

1: xylene / 0.83 h / 150 °C

2: sodium hydroxide / ethanol; H₂O / 7.25 h / Heating

3: 84 percent / H₂, (1S)-(+)-10-camphorsulfonic acid / palladium hydroxide on carbon / ethyl acetate / 22.5 h

4: 85 percent / N-ethyldiisopropylamine / 4-dimethylaminopyridine / CH₂Cl₂ / 1.) 0 deg C, 40 min; 2.) rt,1.33 h

5: lithium diisopropylamide / hexane; tetrahydrofuran / 1.) 0 deg C, 50 min; 2.) rt, 50 min

6: 83 percent / n-BuLi / hexane; tetrahydrofuran / 1.1 h / Ambient temperature

7: 71 percent / dicyclohexylcarbodiimide, pyridine, trifluoroacetic acid, DMSO / benzene / 4.5 h / Ambient temperature

8: 69 percent / camphorsulfonic acid / 2.5 h / Ambient temperature

9: 83 percent / tri-n-butylphosphine / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; sodium hydroxide; n-butyllithium; tributylphosphine; camphor-10-sulfonic acid; hydrogen; dimethyl sulfoxide; (+)-10-camphorsulfonic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium diisopropyl amide; dmap; palladium dihydroxide; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate; xylene; benzene;

DOI:10.1016/S0040-4020(01)83440-2

upstream raw materials:

ortho-nitrophenyl selenocyanate

C₂₄H₃₃NO₃

C₂₄H₃₃NO₃

3,3'-dimethylbutyrolactone

Downstream raw materials:

C₂₉H₃₂N₂O₃Se

C₂₉H₃₂N₂O₃Se