Technology Process of methyl-3-(3,5-dihydroxyphenyl)alanine
There total 8 articles about methyl-3-(3,5-dihydroxyphenyl)alanine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
platinum on activated charcoal;
In
methanol;
for 10h;
Ambient temperature;
DOI:10.1139/v91-004
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / 1.) K2CO3 / acetone / 1.) 0.5 h, 2.) reflux, 1 h
2: 95 percent / LiAlH4 / diethyl ether / 2.5 h / Heating
3: 0.11 g / NaH / benzene / 9 h / Ambient temperature
4: 92 percent / NaH / benzene; dimethylformamide / 1.) 15 min, 2.) room temp., 6 h
5: 1.) 20percent aq. NaOH, 2.) glacial HOAc / 1.) dioxane, reflux, 3 h, 2.) reflux, 1 h
6: hydrazine / 24 h / 100 °C
7: HCl(gas) / 1 h / Heating
8: H2 / Pt-C / methanol / 10 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydride; potassium carbonate; acetic acid; hydrazine;
platinum on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1139/v91-004
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 95 percent / LiAlH4 / diethyl ether / 2.5 h / Heating
2: 0.11 g / NaH / benzene / 9 h / Ambient temperature
3: 92 percent / NaH / benzene; dimethylformamide / 1.) 15 min, 2.) room temp., 6 h
4: 1.) 20percent aq. NaOH, 2.) glacial HOAc / 1.) dioxane, reflux, 3 h, 2.) reflux, 1 h
5: hydrazine / 24 h / 100 °C
6: HCl(gas) / 1 h / Heating
7: H2 / Pt-C / methanol / 10 h / Ambient temperature
With
hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydride; acetic acid; hydrazine;
platinum on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl-formamide; benzene;
DOI:10.1139/v91-004
