(-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Base Information

• Chemical Name: (-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine
• CAS No.: 1123190-79-3
• Molecular Formula: C₃₀H₂₇FN₆O
• Molecular Weight: 506.582

Synonyms:

Chemical Property of (-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Chemical Property:

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Technology Process of (-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

There total 2 articles about (-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-(2-bromo-4-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine (949170-24-5) + 3-pyridylboronic acid (1692-25-7) → (-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (1123190-79-3,1123190-81-7,1123190-80-6)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 18h;

Reference yield:

8-(2-bromo-4-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine (949170-24-5) + Pyridine-3-borane acid (729593-35-5) → (-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (1123190-79-3,1123190-81-7,1123190-80-6)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene;

Reference yield:

(-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine (1123190-79-3,1123190-81-7,1123190-80-6) → (-)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine + (+)-8-(4-fluoro-2-pyridin-3-yl-phenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-phenyl]-vinyl}-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridine

Guidance literature:

With CHIRALPAK IB; In ethanol; hexane; Resolution of racemate;

upstream raw materials:

8-(2-bromo-4-fluorophenyl)-2-{(E)-2-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]vinyl}-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyridine

3-pyridylboronic acid

Pyridine-3-borane acid

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