Technology Process of 1,2,3-Trimethoxy-5-[2-(3-methoxyphenyl)ethyl]benzene
There total 4 articles about 1,2,3-Trimethoxy-5-[2-(3-methoxyphenyl)ethyl]benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3,4,5-trimethoxytoluene;
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium tert-butylate;
In
hexane; n-heptane;
at 0 ℃;
for 0.25h;
Inert atmosphere;
1-bromomethyl-3-methoxybenzene;
In
hexane; n-heptane;
at 0 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/acs.joc.5b01540
- Guidance literature:
-
3,4,5-trimethoxytoluene; 1-methoxy-3-methyl-benzene;
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium tert-butylate;
In
tetrahydrofuran;
at -78 ℃;
for 0.25h;
Inert atmosphere;
With
ethylene dibromide;
In
tetrahydrofuran;
at -78 - 20 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/jo3000805
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
for 4h;
under 2068.6 Torr;
DOI:10.1021/jm00112a036
