2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol

Base Information

Chemical Name:2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol
CAS No.:1363603-26-2
Molecular Formula:C₁₆H₁₃Br₂N₃O₃
Molecular Weight:455.106
Hs Code.:

Synonyms:

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Chemical Property of 2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol

Chemical Property:

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Technology Process of 2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol

There total 7 articles about 2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 673-22-3
2-Hydroxy-4-methoxybenzaldehyde

: 1363603-26-2
2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: ethylmagnesium chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

3.2: 3 h / 50 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; ethylmagnesium chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 2.2: Colvin rearrangement / 3.2: Huisgen cycloaddition;
DOI:10.1016/j.bmc.2012.01.010

Reference yield:

: 609-21-2
2,6-dibromo-4-aminophenol

: 1363603-26-2
2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / 0.5 h / 20 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

3.1: hydrogenchloride / water / 0.17 h / 140 °C / Microwave irradiation

4.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

4.2: 2 h / 0 - 20 °C

5.1: ethylmagnesium chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

5.2: 3 h / 50 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrabutyl ammonium fluoride; ethylmagnesium chloride; potassium carbonate; acetic acid; sodium nitrite; In tetrahydrofuran; water; acetone; 5.2: Huisgen cycloaddition;
DOI:10.1016/j.bmc.2012.01.010

Reference yield:

: 63558-07-6
N-(3,5-dibromo-4-hydroxyphenyl)acetamide

: 1363603-26-2
2-(1-(3,5-dibromo-4-methoxyphenyl)-1H-1,2,3-triazol-5-yl)-5-methoxyphenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogenchloride / water / 0.17 h / 140 °C / Microwave irradiation

3.1: hydrogenchloride; sodium nitrite / water / 1 h / 0 °C

3.2: 2 h / 0 - 20 °C

4.1: ethylmagnesium chloride / tetrahydrofuran / 0.5 h / 50 °C / Inert atmosphere

4.2: 3 h / 50 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; tetrabutyl ammonium fluoride; ethylmagnesium chloride; potassium carbonate; sodium nitrite; In tetrahydrofuran; water; acetone; 4.2: Huisgen cycloaddition;
DOI:10.1016/j.bmc.2012.01.010