Technology Process of Pro-Gln(Mbh)-Gln(Mbh)-D-Trp(Boc)-OMe
There total 14 articles about Pro-Gln(Mbh)-Gln(Mbh)-D-Trp(Boc)-OMe which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / H2 / 5percent Pd/C / methanol; acetic acid / 2 h
2: 88 percent / N-methylmorpholine / dimethylformamide / -10 deg C, 1 h; 4 deg C, overnight
3: 70 percent / dicyclohexylcarbodi-imide, hydroxybenzotriazole*H2O / CH2Cl2 / 0 deg C, 3 h; r.t., overnight
4: trifluoroacetic acid / CH2Cl2
With
4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 99 percent / 4-dimethylaminopyridine / acetonitrile / 2 h
2: 4.46 g / trifluoroacetic acid / CH2Cl2 / 1 h
3: 70 percent / hydroxybenzotriazole*H2O, dicyclohexylcarbodi-imide / CH2Cl2 / 0 °C
4: trifluoroacetic acid / CH2Cl2 / 2 h
5: 70 percent / dicyclohexylcarbodi-imide, hydroxybenzotriazole*H2O / CH2Cl2 / 0 deg C, 3 h; r.t., overnight
6: trifluoroacetic acid / CH2Cl2
With
dmap; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
dichloromethane; acetonitrile;
