5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

Base Information

Chemical Name:5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate
CAS No.:1399281-28-7
Molecular Formula:C₃₆H₄₇NO₆Si
Molecular Weight:617.858
Hs Code.:

5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

Synonyms:

Suppliers and Price of 5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

Chemical Property:

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Useful:

Technology Process of 5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

There total 1 articles about 5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1254102-47-0
4-((tert-butyldimethylsilyloxy)-N-methylamino)benzyl alcohol

: C₂₃H₂₃F₃O₈S

: 1399281-28-7
5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 65 ℃; for 12h; Inert atmosphere;
DOI:10.1002/anie.201201928

Reference yield:

: 1399281-28-7
5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

: C₃₀H₃₃NO₆

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1002/anie.201201928

Reference yield:

: 1399281-28-7
5-(((4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)(methyl)amino)methyl)-2-(((4-methylbenzoyl)oxy)methyl)tetrahydrofuran-3-yl 4-methylbenzoate

: C₅₄H₆₀N₅O₇P

Guidance literature:: Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 0 °C

2: Dess-Martin periodane / dichloromethane / 12 h / 20 °C

3: sodium methylate / methanol; dichloromethane / 4 h / 20 °C

4: piperidine / acetonitrile / 12 h / Inert atmosphere; Reflux

5: pyridine; dmap; silver nitrate / 2 h / 20 °C / Inert atmosphere; Darkness

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere; Darkness

With piperidine; pyridine; dmap; tetrabutyl ammonium fluoride; sodium methylate; Dess-Martin periodane; silver nitrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1002/anie.201201928