ethyl 4-(2-formylphenyl)butanoate

Base Information

• Chemical Name: ethyl 4-(2-formylphenyl)butanoate
• CAS No.: 1346004-43-0
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.268
• Mol file: 1346004-43-0.mol

Synonyms:

Chemical Property of ethyl 4-(2-formylphenyl)butanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(2-formylphenyl)butanoate

There total 1 articles about ethyl 4-(2-formylphenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) → ethyl 4-(2-formylphenyl)butanoate (1346004-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; ethylene dibromide; lithium chloride; zinc / tetrahydrofuran / 12 h / 50 °C / Inert atmosphere

2: PEPPSI / tetrahydrofuran; desipramine / 12 h / 20 °C / Inert atmosphere

With PEPPSI; iodine; ethylene dibromide; lithium chloride; zinc; In tetrahydrofuran; desipramine;

DOI:10.1021/ol202750u

Reference yield:

ethyl 4-(2-formylphenyl)butanoate (1346004-43-0) → (2aR,8bR)-1,3,4,8b-tetrahydronaphtho[1,2-b]azet-2(2aH)-one (874292-65-6,5691-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: magnesium sulfate / dichloromethane / 0.08 h / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: 15-crown-5; sodium hexamethyldisilazane / tetrahydrofuran / 8 h / -40 °C / Inert atmosphere

3.1: ammonium cerium (IV) nitrate / water; acetonitrile / 16 h / Inert atmosphere

With ammonium cerium (IV) nitrate; 15-crown-5; sodium hexamethyldisilazane; magnesium sulfate; In tetrahydrofuran; dichloromethane; water; acetonitrile;

DOI:10.1021/ol202750u

upstream raw materials:

Ethyl 4-bromobutyrate

Downstream raw materials:

(2aR,8bR)-1,3,4,8b-tetrahydronaphtho[1,2-b]azet-2(2aH)-one