methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate

Base Information

Chemical Name:methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate
CAS No.:161453-06-1
Molecular Formula:C₂₅H₂₇NO₃
Molecular Weight:389.494
Hs Code.:

methyl (2R,3R,αR)-3-<N-benzyl-N-(α-methylbenzyl)amino>-2-hydroxy-3-phenylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate

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Technology Process of methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate

There total 10 articles about methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 161453-07-2
(2R,3R,αR)-3--2-hydroxy-3-phenylpropionic acid

: 161453-06-1
methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate

Guidance literature:: In diethyl ether; 1) 0 deg C, 15 min; 2) room temperature, 15 min;

Reference yield: 53.0%

: 161453-16-3
methyl (3R,αR)-3--2-oxo-3-phenylpropionate

: methyl (2S,3R,αR)-3--2-hydroxy-3-phenylpropionate

: 161453-06-1
methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate

Guidance literature:: With sodium tetrahydroborate; In methanol; Ambient temperature;

Reference yield:

: 14990-09-1
tert-butyl cinnamate

: 161453-06-1
methyl (2R,3R,αR)-3--2-hydroxy-3-phenylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) (+)-(camphorsulfonyl)oxaziridine / 1) THF, -78 deg C, 2 h; 2) THF, -78 deg C (1 h), -78 --> 0 deg C (15 min)

2: 87 percent / trifluoroacetic acid / CH₂Cl₂ / Ambient temperature

3: 99 percent / diethyl ether / 1) 0 deg C, 15 min; 2) room temperature, 15 min

With (+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; trifluoroacetic acid; In diethyl ether; dichloromethane;