5-Amino-2-phenyl-7H-1,3,4-oxadiazolo(3,2-a)pyrimidin-7-one

Base Information

• Chemical Name: 5-Amino-2-phenyl-7H-1,3,4-oxadiazolo(3,2-a)pyrimidin-7-one
• CAS No.: 160893-86-7
• Molecular Formula: C₁₁H₈N₄O₂
• Molecular Weight: 228.21
• DSSTox Substance ID: DTXSID10936427
• Nikkaji Number: J625.712G
• Mol file: 160893-86-7.mol

Synonyms:5-Amino-2-phenyl-7H-1,3,4-oxadiazolo(3,2-a)pyrimidin-7-one;160893-86-7;7H-1,3,4-Oxadiazolo(3,2-a)pyrimidin-7-one, 5-amino-2-phenyl-;DTXSID10936427;LS-99341;2-Phenyl-5-amino-7H-1,3,4-oxadiazolo[3,2-a]pyrimidin-7-one;5-Amino-2-phenyl-7H-[1,3,4]oxadiazolo[3,2-a]pyrimidin-7-one

Chemical Property of 5-Amino-2-phenyl-7H-1,3,4-oxadiazolo(3,2-a)pyrimidin-7-one

Chemical Property:

• Vapor Pressure: 3.65E-05mmHg at 25°C
• Boiling Point: 353.2°C at 760 mmHg
• Flash Point: 167.4°C
• Density: 1.57g/cm³
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 228.06472551
• Heavy Atom Count: 17
• Complexity: 446

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NN3C(=CC(=O)N=C3O2)N

Technology Process of 5-Amino-2-phenyl-7H-1,3,4-oxadiazolo(3,2-a)pyrimidin-7-one

There total 3 articles about 5-Amino-2-phenyl-7H-1,3,4-oxadiazolo(3,2-a)pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ethyl 2-cyanoacetate (105-56-6) + 2-amino-5-phenyl-1,3,4-oxadiazole (1612-76-6) → 2-phenyl-5-amino-7H-1,3,4-oxadiazolo<3,2-a>pyrimidin-7-one (160893-86-7)

Guidance literature:

ethyl 2-cyanoacetate; 2-amino-5-phenyl-1,3,4-oxadiazole; With ammonium acetate; at 150 ℃; for 3h;

In 1,4-dioxane; for 3h; Heating;

Reference yield: 30.0%

2-Cyano-N-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetamide (73720-15-7) → 2-phenyl-5-amino-7H-1,3,4-oxadiazolo<3,2-a>pyrimidin-7-one (160893-86-7)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; at 105 ℃; for 20h;

Reference yield:

2-amino-5-phenyl-1,3,4-oxadiazole (1612-76-6) → 2-phenyl-5-amino-7H-1,3,4-oxadiazolo<3,2-a>pyrimidin-7-one (160893-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / MeONa / methanol / 5 h / Heating

2: 30 percent / P₂O₅, MeSO₃H / 20 h / 105 °C

With methanesulfonic acid; sodium methylate; phosphorus pentoxide; In methanol;

upstream raw materials:

2-Cyano-N-(5-phenyl-[1,3,4]oxadiazol-2-yl)-acetamide

ethyl 2-cyanoacetate

2-amino-5-phenyl-1,3,4-oxadiazole