Technology Process of diisopropyl1,2-bis(2-(5-isopropoxy-1-tosylindol-3-yl)ethyl)hydrazine-1,2-dicarboxylate
There total 10 articles about diisopropyl1,2-bis(2-(5-isopropoxy-1-tosylindol-3-yl)ethyl)hydrazine-1,2-dicarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C28H37N3O7S;
With
potassium hydroxide;
In
dimethyl sulfoxide;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
2-(5-isopropoxy-1-tosylindol-3-yl)ethyl methanesulfonate;
In
dimethyl sulfoxide;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1016/j.tetlet.2013.01.133
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 3.25 h / 0 - 20 °C / Inert atmosphere
3.1: triphenylphosphine / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere
4.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
With
tetrabutyl ammonium fluoride; potassium hexamethylsilazane; acetic acid; triphenylphosphine; potassium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
DOI:10.1016/j.tetlet.2013.01.133
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diethyl ether / 0 - 20 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Inert atmosphere; Reflux
3.1: 1H-imidazole / N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere
4.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere
4.2: 3 h / -78 - 20 °C / Inert atmosphere
5.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 3.25 h / 0 - 20 °C / Inert atmosphere
6.1: triethylamine / dichloromethane / 0.42 h / 0 - 20 °C / Inert atmosphere
7.1: potassium hydroxide / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere
7.2: 4 h / 20 °C / Inert atmosphere
With
1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; potassium hexamethylsilazane; acetic acid; triethylamine; potassium hydroxide;
In
tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2013.01.133
