tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate
CAS No.:1429053-33-7
Molecular Formula:C₃₇H₄₃F₄N₃O₇S
Molecular Weight:749.824
Hs Code.:

tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate

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Chemical Property of tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate

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Technology Process of tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate

There total 12 articles about tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198785-14-6
tert-butyl 6-(ethylsulfonyl)-4-iodopyridin-3-ylcarbamate

: 1198785-55-5
5-fluoro-2-((S)-4-hydroxy-2-methyl-4-(trifluoromethyl)hept-6-yn-2-yl)-N-((S)-1-(4-methoxyphenyl)ethyl)benzamide

: 1429053-33-7
tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; In methanol; at 65 ℃; for 3h; Large scale;
DOI:10.1021/jo400079z

Reference yield:

: 1429053-34-8
5-(2-(2-bromo-4-fluorophenyl)propan-2-yl)-2,2-dimethyl-1,3-dioxane-4,6-dione

: 1429053-33-7
tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / N,N-dimethyl-formamide; water / 15 h / 100 °C / Large scale

2.1: pyridine / toluene / 12 h / 60 - 65 °C / Large scale

2.2: 1 h / 50 °C / Large scale

3.1: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 0 - 25 °C / Large scale

3.2: 5 h / 0 - 25 °C / Large scale

3.3: 0.5 h / 0 - 15 °C / Large scale

4.1: (S)-1-isopropyl-pyrrolidine-2-carboxylic acid; diethylzinc / tetrahydrofuran / 20 °C / Large scale

4.2: Large scale

5.1: palladium diacetate; 1,4-diaza-bicyclo[2.2.2]octane / methanol / 3 h / 65 °C / Large scale

With (S)-1-isopropyl-pyrrolidine-2-carboxylic acid; pyridine; 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; diethylzinc; palladium diacetate; sodium hydride; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jo400079z

Reference yield:

: 1198785-52-2
4-(2-bromo-4-fluorophenyl)-1,1,1-trifluoro-4-methylpentan-2-one

: 1429053-33-7
tert-butyl-6-(ethylsulfonyl)-4-((S)-6-(4-fluoro-2-((S)-1-(4-methoxyphenyl)ethylcarbamoyl)phenyl)-4-hydroxy-6-methyl-4-(trifluoromethyl)hept-1-ynyl)pyridin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 18 h / 0 - 25 °C / Large scale

1.2: 5 h / 0 - 25 °C / Large scale

1.3: 0.5 h / 0 - 15 °C / Large scale

2.1: (S)-1-isopropyl-pyrrolidine-2-carboxylic acid; diethylzinc / tetrahydrofuran / 20 °C / Large scale

2.2: Large scale

3.1: palladium diacetate; 1,4-diaza-bicyclo[2.2.2]octane / methanol / 3 h / 65 °C / Large scale

With (S)-1-isopropyl-pyrrolidine-2-carboxylic acid; 1,4-diaza-bicyclo[2.2.2]octane; diethylzinc; palladium diacetate; sodium hydride; In tetrahydrofuran; methanol; mineral oil;
DOI:10.1021/jo400079z