Technology Process of (2E,4E,6E,8E)-9-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid methyl ester
There total 18 articles about (2E,4E,6E,8E)-9-(6,6-Dimethyl-2-trifluoromethyl-cyclohex-1-enyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 14 steps
1: hydrogen / PtO2 / methanol
2: 2,6-lutidune / CH2Cl2
3: 85 percent / p-TsOH / methanol
4: LiBr / acetone
5: 1.) Mg 2.) 3P>4 / THF
6: n-BuF4 / tetrahydrofuran
7: Na2Cr2O7*2H2O, H2SO4 / acetic acid / Ambient temperature
8: 78 percent / LiH / tetrahydrofuran; hexamethylphosphoric acid triamide / 48 h / Heating
9: 73 percent / DIBAL-H / hexane / 24 h / -78 °C
10: 94 percent / MnO2 / CH2Cl2 / 3 h / Ambient temperature
11: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h
12: 94 percent / DIBAL-H / hexane / 1 h / -78 °C
13: 60 percent / MnO2 / CH2Cl2 / 3 h / Ambient temperature
14: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h
With
2,6-dimethylpyridine; manganese(IV) oxide; n-butyllithium; sodium dichromate; tetrakiscopper(I); sulfuric acid; hydrogen; lithium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; magnesium; lithium bromide;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; acetic acid; acetone;
DOI:10.1016/S0040-4039(00)95054-8
- Guidance literature:
-
Multi-step reaction with 15 steps
1: 90.3 percent / NaBH4 / ethanol
2: hydrogen / PtO2 / methanol
3: 2,6-lutidune / CH2Cl2
4: 85 percent / p-TsOH / methanol
5: LiBr / acetone
6: 1.) Mg 2.) 3P>4 / THF
7: n-BuF4 / tetrahydrofuran
8: Na2Cr2O7*2H2O, H2SO4 / acetic acid / Ambient temperature
9: 78 percent / LiH / tetrahydrofuran; hexamethylphosphoric acid triamide / 48 h / Heating
10: 73 percent / DIBAL-H / hexane / 24 h / -78 °C
11: 94 percent / MnO2 / CH2Cl2 / 3 h / Ambient temperature
12: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h
13: 94 percent / DIBAL-H / hexane / 1 h / -78 °C
14: 60 percent / MnO2 / CH2Cl2 / 3 h / Ambient temperature
15: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h
With
2,6-dimethylpyridine; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; sodium dichromate; tetrakiscopper(I); sulfuric acid; hydrogen; lithium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; magnesium; lithium bromide;
platinum(IV) oxide;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; acetic acid; acetone;
DOI:10.1016/S0040-4039(00)95054-8
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 1.) NaH / THF, -78 deg C,
2: 30percent H2O2 / CH2Cl2 / 0 °C
3: 1.) Mg 2.) 3P>4 / THF
4: n-BuF4 / tetrahydrofuran
5: Na2Cr2O7*2H2O, H2SO4 / acetic acid / Ambient temperature
6: 78 percent / LiH / tetrahydrofuran; hexamethylphosphoric acid triamide / 48 h / Heating
7: 73 percent / DIBAL-H / hexane / 24 h / -78 °C
8: 94 percent / MnO2 / CH2Cl2 / 3 h / Ambient temperature
9: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h
10: 94 percent / DIBAL-H / hexane / 1 h / -78 °C
11: 60 percent / MnO2 / CH2Cl2 / 3 h / Ambient temperature
12: 1.) n-BuLi / 1.) THF, -78 deg C 2.) room temperature, 10 h
With
manganese(IV) oxide; n-butyllithium; sodium dichromate; tetrakiscopper(I); sulfuric acid; dihydrogen peroxide; lithium hydride; sodium hydride; diisobutylaluminium hydride; magnesium;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; acetic acid;
DOI:10.1016/S0040-4039(00)95054-8
