Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester
• CAS No.: 113765-05-2
• Molecular Formula: C₄₃H₄₆N₈O₁₃P₂S₃
• Molecular Weight: 1041.03
• Mol file: 113765-05-2.mol

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester

There total 3 articles about Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis<2(methylsulphonyl)ethyl>-phosphochloridate (92483-33-5) → Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester (113765-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 6 h / 0 °C

2: dioxane / 0.5 h / Ambient temperature

With pyridine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)96203-8

Reference yield:

N6-(diphenylacetyl)-2'-deoxyadenosine (95900-44-0) → Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester (113765-05-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 6 h / 0 °C

2: dioxane / 0.5 h / Ambient temperature

With pyridine; In 1,4-dioxane;

DOI:10.1016/S0040-4039(00)96203-8

Reference yield:

S-4-methylphenyl-O,O-bis(1-benzotriazolyl)phosphorothioate (97204-93-8) + Phosphoric acid (2R,3S,5R)-5-(6-diphenylacetylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester (113765-02-9) → Phosphoric acid (2R,3S,5R)-3-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxy]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester (113765-05-2)

Guidance literature:

In 1,4-dioxane; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4039(00)96203-8

upstream raw materials:

S-4-methylphenyl-O,O-bis(1-benzotriazolyl)phosphorothioate

Phosphoric acid (2R,3S,5R)-5-(6-diphenylacetylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester bis-(2-methanesulfonyl-ethyl) ester

bis<2(methylsulphonyl)ethyl>-phosphochloridate

N⁶-(diphenylacetyl)-2'-deoxyadenosine